Metal and metal(loids) removal efficiency using genetically engineered microbes: Applications and challenges

The environment is being polluted in different many with metal and metalloid pollution, mostly due to anthropogenic activity, which is directly affecting human and environmental health. Metals and metalloids are highly toxic at low concentrations and contribute primarily to the survival equilibrium of activities in the environment. However, because of non-degradable, they persist in nature and these metal and metalloids bioaccumulate in the food chain. Genetically engineered microorganisms (GEMs) mediated techniques for the removal of metals and metalloids are considered an environmentally safe and economically feasible strategy. Various forms of GEMs, including fungi, algae, and bacteria have been produced by recombinant DNA and RNA technologies, which have been used to eliminate metal and metalloids compounds from the polluted areas. Besides, GEMs have the potentiality to produce enzymes and other metabolites that are capable of tolerating metals stress and detoxify the pollutants. Thus, the aim of this review is to discuss the use of GEMs as advanced tools to produce metabolites, signaling molecules, proteins through genetic expression during metal and metalloids interaction, which help in the breakdown of persistent pollutants in the environment.

Automated summary

Metal and metalloid pollution, caused by anthropogenic activities, directly impacts human and environmental health. Genetically engineered microorganisms (GEMs) are considered to be an environmentally safe and economically feasible strategy for removing metals and metalloids from polluted areas. GEMs have the potential to produce enzymes and metabolites that can tolerate metal stress and detoxify pollutants, aiding in the breakdown of persistent pollutants in the environment.