Journal
JOURNAL OF FOOD BIOCHEMISTRY
Volume 45, Issue 9, Pages -Publisher
WILEY
DOI: 10.1111/jfbc.13888
Keywords
apoptosis; curcumin; neuroblastoma; reactive oxygen species
Funding
- Guangdong Natural Science Foundation [2020A1515110648, 2019A1515011178]
- Guangzhou Medical University Students' Science and Technology Innovation Project [2019AEK02, 2020AEK03, 2020AEK06, 2020AEK12]
- Open Project of Guangdong Key Laboratory of Marine Materia Medica [LMM2020-7]
- Open Fund of Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications [2020A03]
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Neuroblastoma is a solid tumor with high mortality rates in children, and curcumin has shown anticancer properties in treating these tumors. Curcumin inhibits cell proliferation and migration, induces apoptosis through cell cycle arrest and caspase-3 activation, and promotes ROS overproduction and apoptosis through p53 and Bcl-2 pathways in NB cells.
Neuroblastoma (NB) is a solid tumor in the nervous system and has a high mortality rate in children. Curcumin has well-characterized anticancer properties, while there is no effective method in clinical treatment. MTT assays revealed that curcumin dramatically inhibited the proliferation of SK-N-SH cells. Compared with the control group, curcumin markedly restrained the migration of SK-N-SH cells. Curcumin induced SK-N-SH cell apoptosis by G2/M cycle arrest and activated caspase-3 activity. Furthermore, curcumin promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl-2 signal pathways. This finding demonstrated the application of curcumin is an effective strategy for the therapeutics of NB
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