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JOURNAL OF EXPERIMENTAL MEDICINE
Volume 218, Issue 9, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20211141
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The study reveals that bone morphogenetic proteins and Sox9 promote the transdifferentiation of tumor cells into tumor-derived astrocytes, which can be targeted by BMP inhibitors.
In this issue of JEM, Guo et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202350) examine the importance of tumorderived astrocytes in SHH-medulloblastoma recurrence. They show that tumor cells transdifferentiate to tumor-derived astrocytes via bone morphogenetic proteins and Sox9, which excitingly can be targeted by BMP inhibitors.
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