The early interferon catches the SARS-CoV-2

Editorial Material Critical Care Medicine

Nebulised interferon beta-1a for patients with COVID-19 Comment

Nathan Peiffer-Smadja et al.

LANCET RESPIRATORY MEDICINE (2021)

Review Biochemistry & Molecular Biology

Type I and III interferon responses in SARS-CoV-2 infection

You-Me Kim et al.

Summary: Researchers have reviewed how SARS-CoV-2 manipulates the immune system by inhibiting host IFN responses, leading to delayed and exaggerated inflammation, which contributes to the severity of COVID-19. Further investigations are needed to better understand the mechanisms behind these immune system dysfunctions caused by the virus.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

Add to Collection

Article Immunology

Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs

Jonathan Lopez et al.

Summary: The nasal IFN-I/III signature in mildly symptomatic COVID-19 patients correlates with serum IFN-a(2) levels, while critically ill patients with autoantibodies against IFN-I showed low nasal IFN-I/III scores despite high viral loads. Functional assays confirmed the role of autoantibodies in compromising the antiviral effects of IFN-I at the early stages of SARS-CoV-2 infection.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Add to Collection

Article Immunology

Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics

Nagarjuna R. Cheemarla et al.

Summary: Initial replication of SARS-CoV-2 in the upper respiratory tract is crucial for establishing infection, and the host innate immune defenses play a significant role in restricting early infection. The activity of interferon-stimulated genes (ISGs) impacts viral replication and transmission during infection, and cross-reactive antiviral responses induced by different viruses can provide protection against SARS-CoV-2.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology