Journal
JOURNAL OF ENDOCRINOLOGY
Volume 250, Issue 1, Pages 13-24Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/JOE-21-0049
Keywords
estrogen receptor; skeletal longitudinal growth; growth plate; endochondral formation
Categories
Funding
- National Natural Science Foundation of China [81772292]
Ask authors/readers for more resources
Different subtypes of estrogen receptors may have region-specific influences on longitudinal appendicular and axial growth, providing new insights into the role of estrogen receptors in the development of growth plates during puberty in female mice.
Estrogen receptors (ERs) regulate the development of the growth plate (GP) by binding to estrogen, a phenomenon that determines the growth of skeletal bone. However, the exact mechanisms underlying the regulatory effects of ERs on axial and appendicular growth plates during puberty remain unclear. In the present study, the strategy of ER beta blocking resulted in increased longitudinal elongation of the appendicular bone (P < 0.01), whereas ER alpha blocking suppressed appendicular elongation (P < 0.05). Blocking both ERs did not have opposite effects on axial longitudinal growth. The expression of chondrocyte proliferation genes including collagen II, aggrecan, and Sox9 and hypertrophic marker genes including collagen X, MMP13, and Runx2 was significantly increased in the growth plate of female mice treated with ER beta antagonist compared with that in the GP of control mice (P < 0.05). There were no significant differences in local insulin-like growth factor 1 (IGF-1) expression among these groups (P > 0.05), and Indian hedgehog protein (Ihh) and parathyroid-related protein (PTHrP) expressions differed among these groups (P < 0.05). ERs appeared not to affect axial bone growth during puberty in female mice (P > 0.05). Our data show that the blocking of different ER subtypes might have a region-specific influence on longitudinal appendicular and axial growth.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available