Mo-W-O nanowire intercalated graphene aerogel nanocomposite for the simultaneous determination of dopamine and tyrosine in human urine and blood serum sample

In recent years, most people affected by neurotransmitters and amino acid-related diseases, which cause more disorders in the human brain and body. And hence monitoring the trace level of neurotransmitters and amino acids is necessary. Nowadays transition bimetallic oxides (TBMO's) play a vital role in sensing application due to their unique physical, electrical, and chemical properties. As the carbon-based materials, importantly graphene aerogel (GA) have a high surface area to enhance the conductivity of the electrode material. Here, we reported a molybdenum tungsten oxide nanowire intercalated graphene aerogel (Mo-W-O/GA) nanocomposite-based sensor for the simultaneous detection of dopamine (DA) and tyrosine (Tyr). The proposed Mo-WO/GA nanocomposite was prepared by two steps, facile hydrothermal and freeze-drying method. The formation of the nanocomposite was verified by various spectroscopic techniques. The resulting Mo-W-O/GA/GCE could be used for the quick and sensitive simultaneous determination of DA and Tyr in the presence of other bio interfering compounds. The Mo-W-O/GA sensor exhibited maximum performance toward DA and Tyr under optimum conditions. The sensor parameter such as linear range and lower detection limit (LOD) of Mo-W-O/GA/GCE for the determination of DA was 0.001-448.0 mu M and 0.8 nM respectively, and for the determination Try a linear range of 0.001-478.0 mu M and LOD of 1.4 nM was obtained. The newly proposed sensor was used for precise sensing of DA and Tyr in human urine and blood serum samples with good satisfactory recoveries.

Automated summary

In recent years, the number of people affected by neurotransmitter and amino acid-related diseases has increased, necessitating the monitoring of trace levels of neurotransmitters and amino acids. Transition bimetallic oxides and graphene aerogel-based Mo-W-O/GA nanocomposite sensors show promising performance in detecting dopamine and tyrosine simultaneously. Additionally, these sensors exhibit good sensitivity and selectivity for the precise sensing of dopamine and tyrosine in human biological samples.