Journal
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Volume 64, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jddst.2021.102641
Keywords
Silver nanoparticles; Green synthesis; Microwave assisted; Boletus edulis; Coriolus versicolor anticancer; Antimicrobial; Wound healing
Categories
Funding
- Tokat Gaziosmanpasa University, Foundation of Scientific Researches Projects [2020/104]
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The study demonstrated the successful synthesis of silver nanoparticles using natural extracts with strong anticancer, antibacterial, antifungal, and wound healing potentials.
The green synthesis of metal nanoparticles has been promising approach in the field of nanomedicine due to its low-cost, non-toxic, biocompatible and sustainable features. In literature, therapeutic potentials of silver nanoparticles (AgNPs) coupled with natural extracts have been extensively evaluated against various diseases. The present study aims at preparation of AgNPs using Coriolus versicolor and Boletus edulis mushroom extract based on the microwave-assisted method. The synthesized C. versicolor-silver nanoparticles (CV-AgNPs) and B. edulis-silver nanoparticles (BE-AgNPs) were characterized by UV-Visible spectroscopy, dynamic light scattering technique (DLS) and fourier transform infrared spectroscopy (FTIR). Anticancer activity of AgNPs was tested on MCF-7, HT29 and HUH-7 cell lines. Antimicrobial efficacy of AgNPs was determined against pathogens bacterial (Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus and Enterococcus faecalis) and fungal (Candida albicans and Candida utilis) strains. Also, wound healing potential of AgNPs was examined on L929 cells. Obtained results demonstrated that synthesized CV-AgNPs and BE-AgNPs had an average size diameter of <100 nm and have strong anticancer, antibacterial, antifungal and wound healing potentials.
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