Journal
JOURNAL OF DERMATOLOGY
Volume 48, Issue 10, Pages 1588-1592Publisher
WILEY
DOI: 10.1111/1346-8138.16071
Keywords
coronavirus disease 2019; erythema nodosum; race; severe acute respiratory syndrome coronavirus 2; thrombosis
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A rare case of cutaneous lesions associated with COVID-19 was reported, with histopathological examination revealing inflammation and features of septal panniculitis with cutaneous polyarteritis nodosa. Treatment with non-steroidal anti-inflammatory drugs led to improvement of the skin lesions within 3 weeks. The type and timing of skin manifestations in this case appeared to be uncommon, with noted differences between Western and Asian countries.
In the worldwide coronavirus disease 2019 (COVID-19) outbreak, skin manifestations were seen in COVID-19 patients. We report a case in which a COVID-19 patient developed cutaneous lesions that were diagnosed as erythema nodosum-like lesions, which were associated with COVID-19. Nasopharyngeal swab polymerase chain reaction (PCR) confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathologically, extensive inflammation was seen from the epidermis to the fat tissue. An organized thrombus and disrupted inner elastic lamina were seen in an intradermal vessel. These findings suggest septal panniculitis with cutaneous polyarteritis nodosa. The results of PCR using the specimen of skin lesion was negative. The patient took non-steroidal anti-inflammatory drugs and the skin lesion improved in 3 weeks. To characterize the skin eruption, we reviewed previous reports on COVID-19 (confirmed by the detection of SARS-CoV-2 infection) from Asian countries. The type of eruption and timing of its appearance in this case seemed rare. Differences in skin manifestations between Western and Asian countries were noted.
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