Journal
JOURNAL OF DERMATOLOGICAL TREATMENT
Volume 33, Issue 4, Pages 2250-2256Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2021.1944594
Keywords
photodynamic therapy; actinic keratosis; photoaging; split-face; indoor-daylight; PDT
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This study compared the efficacy and tolerability of cPDT and idlPDT in treating symmetrical AKs on the face and/or scalp, finding that idlPDT was more effective and better tolerated than cPDT.
Background Recently, indoor daylight photodynamic therapy (idl-PDT) has been developed; however, its efficacy and tolerability remain to be assessed. Objective This is a not-inferiority study to compare treatment outcomes of cPDT with a red LED lamp and idlPDT with a polychromatic white LED lamp in adult patients affected by symmetrical AKs of face and/or scalp. Methods In this comparative, intra-patient, split-face, randomized clinical trial forty-three adult patients were enrolled. Two contralateral and symmetrical target areas of the face and/or scalp harboring at least 5 AKs were selected and randomized 1:1 to treatment with cPDT and idlPDT. The AKs number and cumulative area were assessed at baseline (T0). Efficacy and cosmetic outcome were assessed 3 months after treatment (T1). Results Total AKs number and area reduced significantly with both idlPDT (p < .0001) and cPDT (p < .0001) in comparison to baseline. cPDT was more painful (p < .0001) and induced a more severe inflammation (p < .0001). Twenty-nine patients (70.7%) gave their overall preference to idlPDT (p < .001). Conclusion idlPDT may represent an alternative treatment protocol to cPDT for in-office treatment of AKs patients with better tolerability and a not inferior efficacy.
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