Journal
JOURNAL OF DENTAL SCIENCES
Volume 17, Issue 1, Pages 528-534Publisher
ELSEVIER TAIWAN
DOI: 10.1016/j.jds.2021.06.023
Keywords
Bone; Oral health; Tooth loss; Type I collagen; Genetic polymorphisms
Categories
Funding
- Fondazione Cassa di Risparmio di Padova e Rovigo
Ask authors/readers for more resources
Genetic polymorphisms related to bone metabolism, particularly COL1A1 and CALCR, may be associated with tooth loss, contributing to the identification of genes involved in tooth loss and possibly periodontal susceptibility.
Background/purpose: Genetics plays a role in the susceptibility to periodontitis and tooth loss. Several studies examined the involvement of polymorphisms in candidate genes. We hypothesize that bone metabolism-related polymorphisms could be associated with the number of remaining teeth. Materials and methods: Participants in the Pro.V.A. longitudinal Study: 3099 Italians (aged 65+ at baseline), 2196 at follow-up 1 (5yrs), 1641 at follow-up 2 (7yrs) underwent detailed interview and clinical-instrumental examination. Subjects, grouped by remaining teeth number (0, 1-7, 8-19, 20+), were genotyped for six different bone-related polymorphisms: collagen type Ia1 (COL1A1, Sp1, Ss alleles, n = 1068), vitamin D receptor (VDR, Fok I, Ff alleles, n = 300), calcitonin receptor (CALCR, Alu I, CT alleles, n = 1430), estrogen receptor alpha (ESR1, Pvu II and Xba I, Pp and Xx alleles, n = 1335 and n = 1324). Results: COL1A1 associated with dental status: ss carriers had reduced incident tooth loss (p < 0.05). The low frequency of this genotype, 3.6% in the whole population, didn't grant sufficient statistical power to other findings, such as the lower prevalence of edentulism, consistent throughout the study. In men, CC genotype of CALCR was associated with higher tooth loss between follow ups (p < 0.05). Biochemical markers of inflammation didn't differ by genotype. Confounders such as diabetes, neoplasms, and smoking hampered the detrimental effect of S allele in the logistic regression analysis (OR = 0.67, 95% CI 0.4-1.0, p = 0.06). Conclusion: The present study, demonstrating an association between tooth loss and COL1A1 and-in men-CALCR, contributes to the identification of genes involved in tooth loss and, possibly, susceptibility to periodontitis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available