Journal
JOURNAL OF COMPARATIVE NEUROLOGY
Volume 530, Issue 5, Pages 792-803Publisher
WILEY
DOI: 10.1002/cne.25245
Keywords
dopamine; HVC; neurogenesis; song; zebra finch
Categories
Funding
- Whitehall Foundation
- Wesleyan University
- National Science Foundation [DBI-1828327]
- National Institutes of Health [1R15NS123921-01]
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This study found that half of the neurons in the HVC region of adult male zebra finches express activity-dependent genes and are identified as DARPP-32+ HVC neurons, which do not backfill from the robust nucleus of the arcopallium and receive catecholaminergic input.
Adult male zebra finches (Taeniopygia guttata) continually incorporate adult-born neurons into HVC, a telencephalic brain region necessary for the production of learned song. These neurons express activity-dependent immediate early genes (e.g., zenk and c-fos) following song production, suggesting that these neurons are active during song production. Half of these adult-born HVC neurons (HVC NNs) can be backfilled from the robust nucleus of the arcopallium (RA) and are a part of the vocal motor pathway underlying learned song production, but the other half do not backfill from RA, and they remain to be characterized. Here, we used cell birth-dating, retrograde tract tracing, and immunofluorescence to demonstrate that half of all HVC NNs express the phosphoprotein DARPP-32, a protein associated with dopamine receptor expression. We also demonstrate that DARPP-32+ HVC NNs are contacted by tyrosine hydroxylase immunoreactive fibers, suggesting that they receive catecholaminergic input, have transiently larger nuclei than DARPP-32-neg HVC NNs, and do not backfill from RA. Taken together, these findings help characterize a group of HVC NNs that have no apparent projections to RA and so far have eluded positive identification other than HVC NN status.
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