Journal
JOURNAL OF CLINICAL LABORATORY ANALYSIS
Volume 35, Issue 9, Pages -Publisher
WILEY
DOI: 10.1002/jcla.23925
Keywords
apolipoprotein E; coronary artery disease; gene polymorphism; Hakka
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Funding
- Key Scientific and Technological Project of Meizhou People's Hospital [MPHKSTP-20180101]
- Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translation Research of Hakka Population [2018B030322003]
- Science and Technology Program of Meizhou [2019B0202001]
- Scientific Research Cultivation Project of Meizhou People's Hospital [PY-C2020033]
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The study found that the APOE epsilon 4 allele may be associated with susceptibility to CAD in the southern Chinese Hakka population. It indicated that the APOE SNPs rs429358 and rs7412 are associated with CAD, but not the SLCO1B1 gene SNPs rs2306283 and rs4149056.
Objective To analyze the relationship of Apolipoprotein E (APOE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene polymorphisms with coronary artery disease (CAD). Methods 1,129 CAD patients and 1,014 non-CAD controls were included in the study, and relevant information and medical records were collected. The single-nucleotide polymorphisms (SNPs) were analyzed, including rs429358, rs7412 in APOE gene and rs2306283, rs4149056 in SLCO1B1 gene. Results The CAD patients' average age was 66.3 +/- 10.7 years, while 65.5 +/- 12.0 years in controls. The frequencies of APOE allele e3, e4, and e2 were 83.01%, 10.08%, and 6.91% respectively. There were statistically significant differences in genotype e3/e4 (chi(2) = 8.077, p = 0.005) in CAD patients compared with the controls. The SLCO1B1 genotype *1b/*1b and haplotype *1b showed the highest frequency in the study sample. Moreover, epsilon 4 carriers had significantly lower HDL-C, Apo-A1 levels than epsilon 3 carriers among CAD patients, while epsilon 2 carriers showed lower LDL-C, Apo-B level, and higher Apo-A1/Apo-B level than epsilon 3 and epsilon 4 carriers. In controls, epsilon 2 carriers showed lower LDL-C and Apo-B level, higher Apo-A1, and Apo-A1/Apo-B level than epsilon 4 carriers. Logistic regression analysis showed that high LDL-C and Apo-B level, low HDL-C level, smoking, and the epsilon 4 allele were risks for the presence of CAD. Conclusions APOE epsilon 4 allele may be associated with susceptibility to CAD in southern Chinese Hakka population. It indicated that the APOE SNPs rs429358 and rs7412 are associated with CAD, but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene.
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