Journal
JOURNAL OF CLINICAL HYPERTENSION
Volume 23, Issue 8, Pages 1599-1607Publisher
WILEY
DOI: 10.1111/jch.14311
Keywords
ambulatory blood pressure monitoring; hypertension; psychiatric diagnosis; selective serotonin reuptake inhibitors; serotonin-norepinephrine reuptake inhibitors
Categories
Funding
- Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Healthcare Delivery
Ask authors/readers for more resources
This study found that psychiatric patients using SSRIs/SNRIs had significantly higher nighttime systolic and diastolic blood pressure compared to those not using these medications, while there were no significant differences observed between patients with psychiatric diagnosis not on SSRIs/SNRIs. This suggests that the use of SSRIs/SNRIs may be associated with elevated blood pressure levels and further prospective studies are needed to evaluate the impact of these medications on blood pressure.
In this study, the authors aimed to assess both nighttime and daytime blood pressure (BP) variability using 24-hour ambulatory BP monitoring (ABPM) in persons with and without psychiatric conditions and with or without selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) treatment. In this retrospective study, patients who underwent psychiatric evaluation and ABPM within 6 months of each other between January 1, 2012 and December 31, 2017 were identified using billing data. Participants were divided into three groups-participants with no psychiatric diagnosis and no psychiatric medicine (-Diagnosis/-Medication), those with psychiatric diagnosis and on SSRIs/SNRIs (+Diagnosis/+Medication), and psychiatric diagnosis but no psychiatric medications (+Diagnosis/-Medication). Day and nighttime systolic and diastolic BPs were compared between groups controlling for relevant variables using multivariable linear regression models. A total of 475 participants met inclusion criteria including 135 in the -Diagnosis/-Medication group, 232 in the +Diagnosis/+Medication group, and 108 in the +Diagnosis/-Medication group. In adjusted multivariable analysis, the +Diagnosis/+Medication group had higher nighttime systolic BP (median 120 vs 110 mm (Hg); p = .01) and nighttime diastolic BP (median 68 vs 63 mm (Hg); p = .006) as compared to -Diagnosis/-Medication. No statistically significant differences in BPs between the -Diagnosis/-Medication and +Diagnosis/-Medication groups were observed, after adjustment. Use of SSRIs/SNRIs was associated with significantly higher nocturnal systolic and diastolic BP among patients with psychiatric diagnosis using SSRIs/SNRIs but not associated with psychiatric diagnosis without SSRI/SNRI use. SSRIs/SNRIs use may be associated with higher BP levels and this merits future prospective studies using ABPM to assess day and nighttime BP changes with SSRIs/SNRIs use.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available