Journal
JOURNAL OF CLINICAL GASTROENTEROLOGY
Volume 56, Issue 10, Pages E323-E333Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCG.0000000000001608
Keywords
tofacitinib; ulcerative colitis; efficacy; safety; adverse events; remission; JAK inhibitor
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This systematic review and meta-analysis evaluated the effectiveness and safety of tofacitinib in treating moderate-severe ulcerative colitis (UC). Results showed that tofacitinib had good efficacy in inducing remission and clinical response, but higher doses were associated with an increased frequency of adverse events. The clinical response rate after tofacitinib induction was similar in biologic naive and biologic experienced patients.
Background: The objective of our systematic review and meta-analysis was to evaluate the effectiveness and safety of tofacitinib in the treatment of moderate-severe ulcerative colitis (UC). Methods: We searched Medline, Embase, Web of Science, and Cochrane Central to identify articles and abstracts reporting efficacy or safety data on tofacitinib use in UC. Primary outcome assessed was remission. Secondary outcomes included clinical response, steroid free remission, and adverse events (AEs). Results: A total of 26 studies were included. The rates of remission were 29.81% [95% confidence interval (CI): 22.37%-37.25%, I (2): 90%] at week 8, 32.27% (95% CI: 27.67%-36.88%, I (2): 42%) at 6 months and 38.03% (95% CI: 33.59%-42.48%, I (2): 0%) at 1-year. Clinical response rates were 59.41% (95% CI: 55.03%-63.94%, I (2): 61%) at week 8, 48.99% (95% CI: 36.92%-61.06%, I (2): 91%) at 6 months and 50.87% (95% CI: 42.16%-59.58%, I (2): 67%) at 1-year. Odds ratio of clinical response at week 8 in biologic naive versus biologic experienced patients was 1.59 (95% CI: 0.54-4.63). Pooled incidence rate for serious infections, major adverse cardiovascular events, and nonmelanotic squamous cell malignancies across all doses was 4.41 per 100-patient years (PYs) (95% CI: 2.32-8.38 per 100-PY, I (2): 78%), 0.91 per 100-PY (95% CI: 0.43-1.93 per 100-PY, I (2): 37%) and 0.91 per 100-PY (95% CI: 0.61-1.34 per 100-PY, I (2): 0%), respectively. Higher dose was associated with an increased frequency of AEs. Conclusions: While the overall efficacy and safety of tofacitinib in moderate-severe UC is consistent with clinical trial data, the dose dependent increase in AEs highlights the significance of early dose de-escalation. Rate of clinical response after tofacitinb induction was similar in biologic naive and biologic experienced patients.
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