Journal
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 106, Issue 10, Pages E4128-E4141Publisher
ENDOCRINE SOC
DOI: 10.1210/clinem/dgab346
Keywords
gestational diabetes mellitus; gut microbiota; pregnancy; Chinese population
Categories
Funding
- National Natural Science Foundation of China [81930124]
- Fundamental Research Funds for the Central Universities [2019kfyXKJC052]
- Natural Science Foundation of Hubei Province of China [2018CFB197]
- National Key Research and Development Program of China [2017YFC0907504]
- China Postdoctoral Science Foundation [2017M622457]
- STINT from Sweden
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The study aimed to evaluate the association between gut bacterial biomarkers during early pregnancy and the risk of gestational diabetes mellitus (GDM) in Chinese pregnant women. Results showed that gut microbiota in early pregnancy was linked to subsequent GDM risk, with beneficial microorganisms inversely related to GDM incidence and pathogenic members associated with higher incident GDM risk and correlated with glucose levels on OGTT.
Aims: We aimed to assess the association between gut bacterial biomarkers during early pregnancy and subsequent risk of gestational diabetes mellitus (GDM) in Chinese pregnant women. Methods: Within the Tongji-Shuangliu Birth Cohort study, we conducted a nested case-control study among 201 incident GDM cases and 201 matched controls. Fecal samples were collected during early pregnancy (at 6-15 weeks), and GDM was diagnosed at 24 to 28 weeks of pregnancy. Community DNA isolated from fecal samples and V3-V4 region of 16S rRNA gene amplicon libraries were sequenced. Results: In GDM cases versus controls, Rothia, Actinomyces, Bifidobacterium, Adlercreutzia, and Coriobacteriaceae and Lachnospiraceae spp. were significantly reduced, while Enterobacteriaceae, Ruminococcaceae spp., and Veillonellaceae were overrepresented. In addition, the abundance of Staphylococcus relative to Clostridium, Roseburia, and Coriobacteriaceae as reference microorganisms were positively correlated with fasting blood glucose, 1-hour and 2-hour postprandial glucose levels. Adding microbial taxa to the base GDM prediction model with conventional risk factors increased the C-statistic significantly (P < 0.001) from 0.69 to 0.75. Conclusions: Gut microbiota during early pregnancy was associated with subsequent risk of GDM. Several beneficial and commensal gut microorganisms showed inverse relations with incident GDM, while opportunistic pathogenic members were related to higher risk of incident GDM and positively correlated with glucose levels on OGTT.
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