The murburn precepts for cellular ionic homeostasis and electrophysiology

Starting from the basic molecular structure and redox properties of its components, we build a macroscopic cellular electrophysiological model. We first present a murburn purview that could explain ion distribution in bulk-milieu/membrane-interface and support the origin of trans-membrane potential (TMP) in cells. In particular, the discussion focuses on how cells achieve disparity in the distribution of monovalent and divalent cations within (K+ > Na+ > Mg2+ > Ca2+) and outside (Na+ > K+ > Ca2+ > Mg2+). We explore how TMP could vary for resting/graded/action potentials generation and project a model for impulse conduction in neurons. Outcomes based on murburn bioenergetic equilibriums leading to solubilization of ion-pairs, membrane's permittivity, protein channels' fluxes, and proteins' innate ability to bind/adsorb ions selectively are projected as the integral rationale. We also provide experimental modalities to ratify the projections.

Automated summary

This study presents a macroscopic cellular electrophysiological model based on the molecular structure and redox properties of its components, focusing on ion distribution imbalance inside and outside cells and the generation of transmembrane potential. The model includes variations in TMP for different types of potentials and a projection of impulse conduction in neurons. Ultimately, outcomes based on bioenergetic equilibriums provide a comprehensive rationale for the phenomena discussed.