Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 237, Issue 1, Pages 98-117Publisher
WILEY
DOI: 10.1002/jcp.30534
Keywords
ANGPTLs; drug development; inflammation; integrin; metabolism; oligomerization
Categories
Funding
- National Natural Science Foundation of China [31671195, 31971066, 31871411]
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ANGPTLs, a family of secreted glycoproteins, play key roles in lipid metabolism and inflammation. Their potential roles and mechanisms in inflammatory diseases have attracted significant attention from researchers.
Angiopoietin-like proteins (ANGPTLs), a family of eight secreted glycoproteins termed ANGTPL1-8, are involved in angiogenesis, lipid metabolism, cancer progression, and inflammation. Their roles in regulating lipid metabolism have been intensively studied, as some ANGPTLs are promising pharmacological targets for hypertriglyceridemia and associated cardiovascular disease. Recently, the emerging roles of ANGPTLs in inflammation have attracted great attention. First, elevated levels of multiple circulating ANGPTLs in inflammatory diseases make them potential disease biomarkers. Second, multiple ANGPTLs regulate acute or chronic inflammation via various mechanisms, including triggering inflammatory signaling through their action as ligands for integrin or forming homo- /hetero-oligomers to regulate signal transduction via extra- or intracellular mechanisms. As dysregulation of the inflammatory response is a critical trigger in many diseases, understanding the roles of ANGPTLs in inflammation will aid in drug/therapy development. Here, we summarize the roles, mechanisms, and potential therapeutic values for ANGPTLs in inflammation and inflammatory diseases.
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