Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 236, Issue 12, Pages 7938-7965Publisher
WILEY
DOI: 10.1002/jcp.30463
Keywords
apoptosis; cell proliferation; invasion; lncRNA; TNBC; tumorigenesis
Categories
Funding
- DBT-AIST International CENter for Translational and Environmental Research (DAICENTER)
- UGC, New Delhi, India
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Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, primarily affecting younger women. Long noncoding RNAs (lncRNAs) play a crucial role in TNBC treatment, serving as novel diagnostic and prognostic biomarkers. Extensive research is ongoing to uncover the mechanisms through which lncRNAs modulate TNBC progression and treatment.
In recent years, triple-negative breast cancer (TNBC) has emerged as the most aggressive subtype of breast cancer and is usually associated with increased mortality worldwide. The severity of TNBC is primarily observed in younger women, with cases ranging from approximately 12%-24% of all breast cancer cases. The existing hormonal therapies offer limited clinical solutions in completely circumventing the TNBC, with chemoresistance and tumor recurrences being the common hurdles in the path of TNBC treatment. Accumulating evidence has correlated the dysregulation of long noncoding RNAs (lncRNAs) with increased cell proliferation, invasion, migration, tumor growth, chemoresistance, and decreased apoptosis in TNBC. Various clinical studies have revealed that aberrant expression of lncRNAs in TNBC tissues is associated with poor prognosis, lower overall survival, and disease-free survival. Due to these specific characteristics, lncRNAs have emerged as novel diagnostic and prognostic biomarkers for TNBC treatment. However, the underlying mechanism through which lncRNAs perform their actions remains unclear, and extensive research is being carried out to reveal it. Therefore, understanding of mechanisms regulating the modulation of lncRNAs will be a substantial breakthrough in effective treatment therapies for TNBC. This review highlights the association of several lncRNAs in TNBC progression and treatment, along with their possible functions and mechanisms.
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