Journal
JOURNAL OF CELL SCIENCE
Volume 134, Issue 14, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.258757
Keywords
Dedifferentiation; Spermatogenesis; Drosophila; Germ cells
Categories
Funding
- Howard Hughes Medical Institute
- National Institutes of Health Career Training in Reproductive Biology [5T32HD079342-04]
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The translational regulator me31B plays a critical role in preventing excess dedifferentiation in the Drosophila male germline, leading to spermatogonia dedifferentiating into germline stem cells (GSCs) at a dramatically elevated frequency in its absence. The excess dedifferentiation is likely due to misregulation of nos, a key regulator of germ cell identity and GSC maintenance. These findings reveal negative regulation of dedifferentiation to balance stem cell maintenance with differentiation.
Tissue-specific stem cells maintain tissue homeostasis by providing a continuous supply of differentiated cells throughout the life of organisms. Differentiated/differentiating cells can revert back to a stem cell identity via dedifferentiation to help maintain the stem cell pool beyond the lifetime of individual stem cells. Although dedifferentiation is important for maintaining the stem cell population, it is speculated that it underlies tumorigenesis. Therefore, this process must be tightly controlled. Here, we show that a translational regulator, me31B, plays a critical role in preventing excess dedifferentiation in the Drosophila male germline: in the absence of me31B, spermatogonia dedifferentiate into germline stem cells (GSCs) at a dramatically elevated frequency. Our results show that the excess dedifferentiation is likely due to misregulation of nos, a key regulator of germ cell identity and GSC maintenance. Taken together, our data reveal negative regulation of dedifferentiation to balance stem cell maintenance with differentiation.
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