Journal
JOURNAL OF CELL BIOLOGY
Volume 220, Issue 8, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.202106176
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Funding
- Canadian Institutes of Health Research [PJT169125]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-202005388]
- Canada Research Chairs Program [950-231665]
- Cancer Research UK core grant [A17196]
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The study demonstrates that MICAL2 mediates methionine oxidation of ARP3B, disrupting ARP2/3 complexes and causing disassembly of branched actin filaments.
The ARP2/3 complex promotes branched actin networks, but the importance of specific subunit isoforms is unclear. In this issue, Galloni, Carra, et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) show that MICAL2 mediates methionine oxidation of ARP3B, thus destabilizing ARP2/3 complexes and leading to disassembly of branched actin filaments.
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