Related references
Note: Only part of the references are listed.Phase 1 study of single-agent WNT974, a first-in-class Porcupine inhibitor, in patients with advanced solid tumours
Jordi Rodon et al.
BRITISH JOURNAL OF CANCER (2021)
Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading
Alyson Morse et al.
BONE (2020)
Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results
Russell P. Main et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2020)
Proliferating osteoblasts are necessary for maximal bone anabolic response to loading in mice
Heather M. Zannit et al.
FASEB JOURNAL (2020)
Old Mice Have Less Transcriptional Activation But Similar Periosteal Cell Proliferation Compared to Young-Adult Mice in Response to in vivo Mechanical Loading
Christopher J. Chermside-Scabbo et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2020)
Inducible expression of Wnt7b promotes bone formation in aged mice and enhances fracture healing
Deye Song et al.
BONE RESEARCH (2020)
Stimulation of Piezo1 by mechanical signals promotes bone anabolism
Xuehua Li et al.
ELIFE (2019)
An atlas of genetic influences on osteoporosis in humans and mice
John A. Morris et al.
NATURE GENETICS (2019)
Proliferation and Activation of Osterix-Lineage Cells Contribute to Loading-Induced Periosteal Bone Formation in Mice
Heather M. Zannit et al.
JBMR PLUS (2019)
Evaluation of loading parameters for murine axial tibial loading: Stimulating cortical bone formation while reducing loading duration
David Sun et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2018)
Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice
Thomas Funck-Brentano et al.
JOURNAL OF ENDOCRINOLOGY (2018)
Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand
Julia Luther et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy
Babita Madan et al.
BONE RESEARCH (2018)
Old age and the associated impairment of bones' adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycle
Gabriel L. Galea et al.
GENE (2017)
Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis
Kyu Sang Joeng et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Sost deficiency led to a greater cortical bone formation response to mechanical loading and altered gene expression
David Pflanz et al.
SCIENTIFIC REPORTS (2017)
Transcriptional profiling of cortical versus cancellous bone from mechanically-loaded murine tibiae reveals differential gene expression
Natalie H. Kelly et al.
BONE (2016)
Activation of Wnt Signaling by Mechanical Loading Is Impaired in the Bone of Old Mice
Nilsson Holguin et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2016)
In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism
N. Lara-Castillo et al.
BONE (2015)
Role of WNT16 in the Regulation of Periosteal Bone Formation in Female Mice
Jon E. Wergedal et al.
ENDOCRINOLOGY (2015)
NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma
S. Zhao et al.
ONCOGENE (2015)
Aging diminishes lamellar and woven bone formation induced by tibial compression in adult C57BL/6
Nilsson Holguin et al.
BONE (2014)
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures
Sofia Moverare-Skrtic et al.
NATURE MEDICINE (2014)
Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation
Si Hui Tan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
WNT7B Promotes Bone Formation in part through mTORC1
Jianquan Chen et al.
PLOS GENETICS (2014)
Inactivation of Lrp5 in osteocytes reduces Young's modulus and responsiveness to the mechanical loading
Liming Zhao et al.
BONE (2013)
Regulation of Wnt/β-catenin signaling within and from osteocytes
Travis A. Burgers et al.
BONE (2013)
Standardized Nomenclature, Symbols, and Units for Bone Histomorphometry: A 2012 Update of the Report of the ASBMR Histomorphometry Nomenclature Committee
David W. Dempster et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2013)
Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches
Ernesto Canalis
NATURE REVIEWS ENDOCRINOLOGY (2013)
A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice
Kevin A. Maupin et al.
BONE RESEARCH (2013)
Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
Xiaolin Tu et al.
BONE (2012)
Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner
Paul J. Niziolek et al.
BONE (2012)
Wnt/β-Catenin Signaling and Disease
Hans Clevers et al.
CELL (2012)
Wntless functions in mature osteoblasts to regulate bone mass
Zhendong Zhong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Gene Expression Patterns in Bone Following Mechanical Loading
Sara M. Mantila Roosa et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2011)
Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome
Jared J. Barrott et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Generation of Mice with a Conditional Null Allele for Wntless
April C. Carpenter et al.
GENESIS (2010)
Mechanical loading thresholds for lamellar and woven bone formation
Charles H. Turner et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2010)
Aged Mice Have Enhanced Endocortical Response and Normal Periosteal Response Compared With Young-Adult Mice Following 1 Week of Axial Tibial Compression
Michael D. Brodt et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2010)
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Linda Madisen et al.
NATURE NEUROSCIENCE (2010)
Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation
Jiang Fu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
Alexander G. Robling et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment
Kimihiko Sawakami et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells
Carla Bänziger et al.
CELL (2006)
Wnt proteins are lipid-modified and can act as stem cell growth factors
K Willert et al.
NATURE (2003)
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
W Balemans et al.
HUMAN MOLECULAR GENETICS (2001)