Journal
JOURNAL OF BIOPHOTONICS
Volume 14, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.202100191
Keywords
autofluorescence; dental biofilm; gingivitis; microvasculature; optical coherence tomography
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Funding
- Colgate-Palmolive Company
- Washington Research Foundation
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This article presents a case study tracking the resolution of gingivitis over 10 days, utilizing OCT and LIAF technologies. It was found that OCT and LIAF can distinctly capture changes during gingivitis resolution, with evidence of angiogenesis in the acute inflammatory region. Gingival thickness and vessel numbers showed significant changes during the resolution of inflammation.
Gingivitis is highly prevalent in adults, and if left untreated, can progress to periodontitis. In this article, we present an interesting case study where the resolution of gingivitis was followed over a period of 10 days using optical coherence tomography (OCT) and light-induced autofluorescence (LIAF). We demonstrate that OCT and its functional angiography can distinctively capture the changes during the resolution of gingivitis; while LIAF can detect red-fluorescent signals associated with mature plaque present at the inflamed site. The acute inflammatory region showed evidence of angiogenesis based on the quantification of vessel density and number; while no angiogenesis was detected within the less inflamed region. Gingival thickness showed a reduction of 140 +/- 26 mu m on average, measured between the peak gingivitis event and the period wherein the inflammation was resolved. Vessels in the angiogenesis site was found to reduce exponentially. The mildly inflamed site showed a decreasing trend in the vessel size, which however was within the error of the measurement.
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