Journal
JOURNAL OF BIOPHOTONICS
Volume 14, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.202100169
Keywords
calibration; chemical analysis; diffuse optical spectroscopy; porcine adipose; tissue lipid; tissue water
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Funding
- Ministry of Science and ICT and MOE [NRF-2018K1A4A3A02060572, NRF-2019R1I1A3A01062141, NRF-2020H1D3A1A04080958]
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Frequency domain diffuse optical spectroscopy (fdDOS) is a noninvasive technique used to estimate tissue composition and hemodynamics, and can be calibrated using liquid and solid phantoms for comparison with direct chemical analysis (CA). Results showed average errors and standard deviations of 1.9 +/- 0.2% and -0.9 +/- 0.2% for water content, and -9.3 +/- 1.3% and 0.8 +/- 1.3% for fat content measured by fdDOS compared to CA.
Frequency domain diffuse optical spectroscopy (fdDOS) is a noninvasive technique to estimate tissue composition and hemodynamics. While fdDOS has been established as a valuable modality for clinical research, comparison of fdDOS with direct chemical analysis (CA) methods has yet to be reported. To compare the two approaches, we propose a procedure to confirm accurate calibration by use of liquid emulsion and solid silicone phantoms. Tissue fat (FAT) and water (H2O) content of two ex vivo porcine tissue samples were optically measured by fdDOS and compared to CA values. We show an average H2O error (fdDOS minus CA) and SD of 1.9 +/- 0.2% and -0.9 +/- 0.2% for the two samples. For FAT, we report a mean error of -9.3 +/- 1.3% and 0.8 +/- 1.3%. We also measured various body sites of a healthy human subject using fdDOS with results suggesting that accurate calibration may improve device sensitivity.
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