Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1002/jbm.a.37288
Keywords
breast cancer recurrence; curcumin; electrospun nanofiber; mesoporous silica nanoparticles
Funding
- National Natural Science Foundation of China [22005104]
- China Postdoctoral Science Foundation [2019M652875]
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The study developed a novel drug-loaded nanofibrous scaffold using electrospinning, which showed a higher cytotoxicity and more pronounced anticancer effect through a combination of burst and sustained release mechanisms. This approach may have a highly promising application as a localized implantable scaffold for potential postoperative breast cancer therapy.
Electrospun nanofibers (NFs)-based drug delivery approaches are of particular interest as a hopeful implantable nanoplatform for localized cancer therapy and treating tissue defect after resection, allowing the on-site drug delivery with minimal side effect to healthy cells. To maintain therapeutic concentrations of anticancer molecules for a relatively long time through a combination of burst and sustained drug release mechanisms, a hybrid of polycaprolactone and gelatin (PCL/GEL) was used for co-encapsulation of free curcumin (CUR) and CUR-loaded mesoporous silica nanoparticles (CUR@MSNs) via electrospinning, resulting in a novel drug-loaded nanofibrous scaffold, CUR/CUR@MSNs-NFs. The as-prepared MSNs and composite NFs were characterized via TGA, FTIR, FE-SEM, TEM, and BET. In vitro release profile of CUR from CUR/CUR@MSNs-NFs was examined, and the in vitro antitumor efficacy against MDA-MB-231 breast cancer cells was also evaluated through MTT, scratch assay, DAPI staining, and real-time PCR. The results disclosed that the smooth, bead-free, and randomly oriented CUR/CUR@MSNs-NFs displayed a combination of initial rapid discharge and sustained release for CUR, which led to higher cytotoxicity, lower migration as well as a more pronounced effect on apoptosis induction than CUR-NFs and CUR@MSNs-NFs. The present study illustrated that the dual drug release mechanisms through MSN/NF-mediated drug delivery systems might have a highly hopeful application as a localized implantable scaffold for potential postoperative breast cancer therapy.
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