Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 36, Issue 2, Pages 276-288Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/08853282211025912
Keywords
Spinal cord injury; nerve growth factor; macrophage membrane; nanovesicles; neuroprotection
Funding
- Youth Project of Liaoning Education Department [JYTQN201919]
- Natural Science Foundation of Liaoning Province [20180550155]
- National Natural Science Foundation of China [81671907, 81871556, 82072165]
- LiaoNing Revitalization Talents Program [XLYC1902108]
- Scientific Research Project of the Educational Department of Liaoning Province [JYTQN201917]
- Liaoning Provincial Key Laboratory of Marine Bioactive Substances and Technological Innovation Center of Liaoning Pharmaceutical Action and Quality Evaluation [2020-10]
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Nanovesicles encapsulating NGF (NGF-NVs) derived from macrophage membrane were prepared as a drug carrier for SCI treatment, showing promising effects in both cell and animal experiments.
Spinal cord injury (SCI) is an extremely destructive central nervous system lesion. Studies have shown that NGF can promote nerve regeneration after SCI. However, it cannot produce the desired effect due to its stability in the body and is difficulty in passing through the blood-brain barrier. In this study, we prepared nanovesicles derived from macrophage membrane encapsulating NGF (NGF-NVs) as a drug carrier for the treatment of SCI. Cell experiments showed that NGF-NVs were effectively taken up by PC12 cells and inhibited neuronal apoptosis. In vivo imaging experiments, a large quantity of NGF was delivered to the injured site with the aid of the good targeting of NVs. In animal experiments, NGF-NVs improved the survival of neurons by significantly activating the PI3K/AKT signaling pathway and had good behavioral and histological recovery effects after SCI. Therefore, NVs are a potential drug delivery vector for SCI therapy.
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