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CELL METABOLISM (2017)
Recent progress on nuclear receptor RORγ modulators
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
The circadian clock modulates anti-cancer properties of curcumin
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BMC CANCER (2016)
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Bart A. W. Jacobs et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2016)
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Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML
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CELL (2016)
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Circadian Rhythm Disruption Promotes Lung Tumorigenesis
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CELL METABOLISM (2016)
The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome
Baokun He et al.
CELL METABOLISM (2016)
Chronotherapy: Intuitive, Sound, FoundedaEuro¦But Not Broadly Applied
Julia M. Selfridge et al.
DRUGS (2016)
The circadian coordination of cell biology
Amandine Chaix et al.
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Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes
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Comparison between the impact of morning and evening doses of rivaroxaban on the circadian endogenous coagulation rhythm in healthy subjects
S. Brunner-Ziegler et al.
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Clock-driven vasopressin neurotransmission mediates anticipatory thirst prior to sleep
C. Gizowski et al.
NATURE (2016)
ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer
Junjian Wang et al.
NATURE MEDICINE (2016)
Circadian rhythms of liver physiology and disease: experimental and clinical evidence
Yu Tahara et al.
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The Circadian System: A Regulatory Feedback Network of Periphery and Brain
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Clobazam higher-evening differential dosing as an add-on therapy in refractory epilepsy
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SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2016)
Circadian System and Glucose Metabolism: Implications for Physiology and Disease
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TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)
Circadian Rhythms, Sleep, and Disorders of Aging
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TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)
Morning vaccination enhances antibody response over afternoon vaccination: A cluster-randomised trial
Joanna E. Long et al.
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Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity
Peter S. Cunningham et al.
SCIENTIFIC REPORTS (2016)
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Dirk van Moorsel et al.
MOLECULAR METABOLISM (2016)
The Relationship Between Time of Day of Physical Activity and Obesity in Older Women
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A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
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Linjie Sun et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Sumoylation controls CLOCK-BMAL1-mediated clock resetting via CBP recruitment in nuclear transcriptional foci
Yool Lee et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)
Light therapy for better mood and insulin sensitivity in patients with major depression and type 2 diabetes: a randomised, double-blind, parallel-arm trial
Annelies Brouwer et al.
BMC PSYCHIATRY (2015)
Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology
Tami A. Martino et al.
JOURNAL OF BIOLOGICAL RHYTHMS (2015)
Doxorubicin resistance in breast cancer is driven by light at night-induced disruption of the circadian melatonin signal
Shulin Xiang et al.
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Identification of Circadian Determinants of Cancer Chronotherapy through In Vitro Chronopharmacology and Mathematical Modeling
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MOLECULAR CANCER THERAPEUTICS (2015)
Clocking in: chronobiology in rheumatoid arthritis
Frank Buttgereit et al.
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Time-restricted feeding attenuates age-related cardiac decline in Drosophila
Shubhroz Gill et al.
SCIENCE (2015)
KPNB1 mediates PER/CRY nuclear translocation and circadian clock function
Yool Lee et al.
ELIFE (2015)
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ONCOGENE (2015)
Clocks and Cardiovascular Function
Sarah C. McLoughlin et al.
CIRCADIAN RHYTHMS AND BIOLOGICAL CLOCKS, PT B (2015)
Antiobesity Effect of a Small Molecule Repressor of RORγ
Mi Ra Chang et al.
MOLECULAR PHARMACOLOGY (2015)
Identification and Validation of Cryptochrome Inhibitors That Modulate the Molecular Circadian Clock
Sung Kook Chun et al.
ACS CHEMICAL BIOLOGY (2014)
The circadian timing system in clinical oncology
Pasquale F. Innominato et al.
ANNALS OF MEDICINE (2014)
Cross-talk between the circadian clock and the cell cycle in cancer
Matus Sotak et al.
ANNALS OF MEDICINE (2014)
Polymorphism of circadian clock genes and prophylactic lithium response
Janusz K. Rybakowski et al.
BIPOLAR DISORDERS (2014)
Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer
Robert T. Dauchy et al.
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Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Christoph A. Thaiss et al.
CELL (2014)
Diet and Feeding Pattern Affect the Diurnal Dynamics of the Gut Microbiome
Amir Zarrinpar et al.
CELL METABOLISM (2014)
Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges
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CELL METABOLISM (2014)
Overexpression of the Circadian Clock Gene Bmal1 Increases Sensitivity to Oxaliplatin in Colorectal Cancer
Zhao-lei Zeng et al.
CLINICAL CANCER RESEARCH (2014)
A circadian gene expression atlas in mammals: Implications for biology and medicine
Ray Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Effect of aspirin intake at bedtime versus on awakening on circadian rhythm of platelet reactivity A randomised cross-over trial
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THROMBOSIS AND HAEMOSTASIS (2014)
Small molecule SIRT1 activators for the treatment of aging and age-related diseases
Basil P. Hubbard et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2014)
Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour
Subhashis Banerjee et al.
NATURE COMMUNICATIONS (2014)
Machine Learning Helps Identify CHRONO as a Circadian Clock Component
Ron C. Anafi et al.
PLOS BIOLOGY (2014)
Voluntary exercise can strengthen the circadian system in aged mice
T. L. Leise et al.
AGE (2013)
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
Erik S. Musiek et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Optimized Chemical Probes for REV-ERBα
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JOURNAL OF MEDICINAL CHEMISTRY (2013)
Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy
Estelle Woldt et al.
NATURE MEDICINE (2013)
Chronotherapy improves blood pressure control and reduces vascular risk in CKD
Ramon C. Hermida et al.
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Aberrant Expression of Clock Gene Period1 and Its Correlations with the Growth, Proliferation and Metastasis of Buccal Squamous Cell Carcinoma
Ningbo Zhao et al.
PLOS ONE (2013)
Effect of circadian clock mutations on DNA damage response in mammalian cells
Shobhan Gaddameedhi et al.
CELL CYCLE (2012)
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori et al.
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Voluntary scheduled exercise alters diurnal rhythms of behaviour, physiology and gene expression in wild-type and vasoactive intestinal peptide-deficient mice
Analyne M. Schroeder et al.
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Circadian Gating of Epithelial-to-Mesenchymal Transition in Breast Cancer Cells Via Melatonin-Regulation of GSK3β
Lulu Mao et al.
MOLECULAR ENDOCRINOLOGY (2012)
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
Laura A. Solt et al.
NATURE (2012)
The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines
Julie E. Gibbs et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Identification of Small Molecule Activators of Cryptochrome
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Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption
Orfeu M. Buxton et al.
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Identification of SR3335 (ML-176): A Synthetic RORα Selective Inverse Agonist
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Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder A Randomized Placebo-Controlled Trial
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ARCHIVES OF GENERAL PSYCHIATRY (2011)
Light at Night Activates IGF-1R/PDK1 Signaling and Accelerates Tumor Growth in Human Breast Cancer Xenografts
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Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance
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Higher evening antiepileptic drug dose for nocturnal and early-morning seizures
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EPILEPSY & BEHAVIOR (2011)
The Primary Benefits of Angiotensin-Converting Enzyme Inhibition on Cardiac Remodeling Occur During Sleep Time in Murine Pressure Overload Hypertrophy
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The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors
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PLOS ONE (2011)
A Combined Experimental and Mathematical Approach for Molecular-based Optimization of Irinotecan Circadian Delivery
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PLOS COMPUTATIONAL BIOLOGY (2011)
INFLUENCE OF CIRCADIAN TIME OF HYPERTENSION TREATMENT ON CARDIOVASCULAR RISK: RESULTS OF THE MAPEC STUDY
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CHRONOBIOLOGY INTERNATIONAL (2010)
Ischemia/Reperfusion Tolerance Is Time-of-Day-Dependent Mediation by the Cardiomyocyte Circadian Clock
David J. Durgan et al.
CIRCULATION RESEARCH (2010)
Circadian clock control of the cellular response to DNA damage
Aziz Sancar et al.
FEBS LETTERS (2010)
Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock
Yool Lee et al.
JOURNAL OF CELL SCIENCE (2010)
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes
Qing-Jun Meng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
Tae-Hong Kang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Tumor Growth Rate Determines the Timing of Optimal Chronomodulated Treatment Schedules
Samuel Bernard et al.
PLOS COMPUTATIONAL BIOLOGY (2010)
Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm
Xiaoming Yang et al.
BREAST CANCER RESEARCH AND TREATMENT (2009)
Epigenetic Inactivation of the Circadian Clock Gene BMAL1 in Hematologic Malignancies
Hiroaki Taniguchi et al.
CANCER RESEARCH (2009)
LIVER CIRCADIAN CLOCK, A PHARMACOLOGIC TARGET OF CYCLIN-DEPENDENT KINASE INHIBITOR SELICICLIB
Ida Iurisci et al.
CHRONOBIOLOGY INTERNATIONAL (2009)
THE CIRCADIAN CLOCK GENE PER1 SUPPRESSES CANCER CELL PROLIFERATION AND TUMOR GROWTH AT SPECIFIC TIMES OF DAY
Xiaoming Yang et al.
CHRONOBIOLOGY INTERNATIONAL (2009)
Identifying mechanisms of chronotolerance and chronoefficacy for the anticancer drugs 5-fluorouracil and oxaliplatin by computational modeling
Atilla Altinok et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2009)
Circadian oscillation of nucleotide excision repair in mammalian brain
Tae-Hong Kang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Chronotherapy with nifedipine GITS in hypertensive patients:: Improved efficacy and safety with bedtime dosing
Ramon C. Hermida et al.
AMERICAN JOURNAL OF HYPERTENSION (2008)
Chronotherapy improves blood pressure control and reverts the nondipper pattern in patients with resistant hypertension
Ramon C. Hermida et al.
HYPERTENSION (2008)
The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice
J. D. Alvarez et al.
JOURNAL OF BIOLOGICAL RHYTHMS (2008)
Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex
Jiwon Lee et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis
Patricia A. Wood et al.
MOLECULAR CANCER RESEARCH (2008)
Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production
Gi Hoon Son et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Preliminary evidence that morning vaccination is associated with an enhanced antibody response in men
Anna C. Phillips et al.
PSYCHOPHYSIOLOGY (2008)
Influence of circadian rhythm on the efficacy of the hepatitis B vaccination
Oguz Karabay et al.
VACCINE (2008)
High-fat diet disrupts behavioral and molecular circadian rhythms in mice
Akira Kohsaka et al.
CELL METABOLISM (2007)
Acute risk factors for myocardial infarction
Viktor Culic
INTERNATIONAL JOURNAL OF CARDIOLOGY (2007)
Improved tumor control through circadian clock induction by seliciclib, a cyclin-dependent kinase inhibitor
Ida Iurisci et al.
CANCER RESEARCH (2006)
Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock
Roman V. Kondratov et al.
GENES & DEVELOPMENT (2006)
Chronotherapeutic dose schedule of phenytoin and carbamazepine in epileptic patients
Radha Yegnanarayan et al.
CHRONOBIOLOGY INTERNATIONAL (2006)
Chronomodulated irinotecan, oxaliplatin, and leucovorin-modulated 5-fluorouracil as ambulatory salvage therapy in patients with irinotecan- and oxaliplatin-resistant metastatic colorectal cancer
Dany Gholam et al.
ONCOLOGIST (2006)
Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats
DE Blask et al.
CANCER RESEARCH (2005)
Light activates the adrenal gland: Timing of gene expression and glucocorticoid release
A Ishida et al.
CELL METABOLISM (2005)
Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer
MA Gauger et al.
CANCER RESEARCH (2005)
Circadian clock genes as modulators of sensitivity to genotoxic stress
MP Antoch et al.
CELL CYCLE (2005)
Captopril administered at night restores the diurnal blood pessure rhythm in adequately controlled, nondipping hypertensives
YG Qiu et al.
CARDIOVASCULAR DRUGS AND THERAPY (2005)
Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome
Y Xu et al.
NATURE (2005)
Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex
VY Gorbacheva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Circadian rhythm in dihydropyrimidine dehydrogenase activity and reduced glutathione content in peripheral blood of nasopharyngeal carcinoma patients
ZL Zeng et al.
CHRONOBIOLOGY INTERNATIONAL (2005)
Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor
TG Granda et al.
FASEB JOURNAL (2004)
Control mechanism of the circadian clock for timing of cell division in vivo
T Matsuo et al.
SCIENCE (2003)
Taking simvastatin in the morning compared with in the evening: randomised controlled trial
A Wallace et al.
BRITISH MEDICAL JOURNAL (2003)
The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo
LN Fu et al.
CELL (2002)
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