4.6 Article

UGT86C11 is a novel plant UDP-glycosyltransferase involved in labdane diterpene biosynthesis

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Glycosylation of N-hydroxy-pipecolic acid equilibrates between systemic acquired resistance response and plant growth

Jianghua Cai et al.

Summary: NHP glycosylation is a critical factor in balancing plant defense and growth, with UGT76B1 controlling the NHP/NHPG ratio to fine-tune SAR response and plant development. UGT76B1-mediated NHP glycosylation acts as a hand brake on NHP accumulation upon pathogen attack, adding complexity to SAR-associated networks.

MOLECULAR PLANT (2021)

Review Biochemistry & Molecular Biology

Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism

Rafael Agustin Burgos et al.

Summary: Andrographolide, the main active ingredient isolated from Andrographis paniculata, possesses diverse biological effects including anti-inflammatory, antioxidant, and antineoplastic properties. Its targets include transcription factors NF-kappa B, AP-1, and HIF-1, as well as signaling pathways such as PI3K/Akt, MAPK, and JAK/STAT. The increase in Nrf2 signaling pathway supports its antioxidant and anti-inflammatory properties, while recent evidence suggests that andrographolide may modulate glucose metabolism, potentially explaining its diverse therapeutic effects.

MOLECULES (2021)

Article Pharmacology & Pharmacy

Andrographolide inhibits IL-1β release in bone marrow-derived macrophages and monocyte infiltration in mouse knee joints induced by monosodium urate

Chia-Wen Lo et al.

Summary: The study aimed to investigate the effects of Andrographolide (AND) on gout-induced joint inflammation. The results demonstrated that AND attenuated MSU-induced joint inflammation by inducing HO-1 expression and inhibiting ROS-mediated NLRP3 inflammasome assembly and subsequent IL-1 beta release.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

Article Plant Sciences

Application of virus-induced gene silencing in Andrographis paniculata, an economically important medicinal plant

Anchal Garg et al.

Summary: The study successfully applied virus-induced gene silencing technology to achieve targeted silencing of phytoene desaturase in kalmegh, resulting in a typical photobleaching phenotype. This provides a useful method for studying gene functions related to medicinal and agricultural traits in kalmegh.

PROTOPLASMA (2021)

Review Plant Sciences

Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents

Maoyuan Jiang et al.

Summary: Andrographis paniculata is widely used in subtropical regions for treating various ailments and has potential antiviral properties.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Plant Sciences

BAHD acetyltransferase contributes to wound-induced biosynthesis of oleo-gum resin triterpenes in Boswellia

Aashish Kumar et al.

Summary: Triterpenes are important natural compounds with various physiological functions in plants, with the special oleo-gum resin of Boswellia trees containing enriched boswellic acids (BAs) with medicinal properties. The enzyme BsAT1 was identified as catalyzing late-stage C3 alpha-O-acetylation reactions in the biosynthetic pathway of BAs in response to wound-induced biosynthesis. The study provides new insights into the biosynthesis of principal chemical constituents of Boswellia oleo-gum resin.

PLANT JOURNAL (2021)

Article Biochemistry & Molecular Biology

Specific decorations of 17-hydroxygeranyilinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata

Sven Heiling et al.

Summary: This study confirmed the defensive function of glucosylation and malonylation steps in HGL-DTG biosynthesis through gene silencing, highlighting that glucosylation is a critical step in generating defensive metabolites.

PLANT CELL (2021)

Article Plant Sciences

UGT84F9 is the major flavonoid UDP-glucuronosyltransferase in Medicago truncatula

Olubu A. Adiji et al.

Summary: Mammalian phase II metabolism of dietary plant flavonoid compounds involves glucuronidation, while in plants, flavonoids mainly exist as glucose conjugates. In the model legume Medicago truncatula, flavones apigenin and luteolin are major flavonoid compounds present in aerial parts. The glycosyltransferase UGT84F9 in M. truncatula is essential for formation of flavonoid glucuronides in planta but not for most flavonoid glucosides, highlighting its potential use in semi-synthesis of flavonoid phase II metabolites for clinical studies.

PLANT PHYSIOLOGY (2021)

Review Cell Biology

Combinatorial Control of Plant Specialized Metabolism: Mechanisms, Functions, and Consequences

Elia Lacchini et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 36, 2020 (2020)

Article Plant Sciences

UDP-glucosyltransferase PpUGT85A2 controls volatile glycosylation in peach

Boping Wu et al.

JOURNAL OF EXPERIMENTAL BOTANY (2019)

Article Biotechnology & Applied Microbiology

Overexpression of SrUGT76G1 in Stevia alters major steviol glycosides composition towards improved quality

Mi Jung Kim et al.

PLANT BIOTECHNOLOGY JOURNAL (2019)

Review Plant Sciences

Why do plants produce so many terpenoid compounds?

Eran Pichersky et al.

NEW PHYTOLOGIST (2018)

Article Biochemistry & Molecular Biology

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

Sudhir Kumar et al.

MOLECULAR BIOLOGY AND EVOLUTION (2018)

Article Plant Sciences

Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus

Allison M. Heskes et al.

PLANT JOURNAL (2018)

Review Biotechnology & Applied Microbiology

Plant secondary metabolism linked glycosyltransferases: An update on expanding knowledge and scopes

Pragya Tiwari et al.

BIOTECHNOLOGY ADVANCES (2016)

Article Plant Sciences

De novo Assembly of Leaf Transcriptome in the Medicinal Plant Andrographis paniculata

Neeraja Cherukupalli et al.

FRONTIERS IN PLANT SCIENCE (2016)

Review Plant Sciences

P450s and UGTs: Key Players in the Structural Diversity of Triterpenoid Saponins

Hikaru Seki et al.

PLANT AND CELL PHYSIOLOGY (2015)

Article Biochemistry & Molecular Biology

AtUGT76C2, an Arabidopsis cytokinin glycosyltransferase is involved in drought stress adaptation

Yan-jie Li et al.

PLANT SCIENCE (2015)

Article Plant Sciences

Functional diversification of two UGT80 enzymes required for steryl glucoside synthesis in Arabidopsis

Daniel F. Stucky et al.

JOURNAL OF EXPERIMENTAL BOTANY (2015)

Review Plant Sciences

To Gibberellins and Beyond! Surveying the Evolution of (Di)Terpenoid Metabolism

Jiachen Zi et al.

ANNUAL REVIEW OF PLANT BIOLOGY, VOL 65 (2014)

Article Multidisciplinary Sciences

Genomic Signatures of Specialized Metabolism in Plants

Lee Chae et al.

SCIENCE (2014)

Article Biochemistry & Molecular Biology

Glycosyltransferases from Oat (Avena) Implicated in the Acylation of Avenacins

Amorn Owatworakit et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Chemistry, Medicinal

Hypolipidemic Effects of Andrographolide and Neoandrographolide in Mice and Rats

Tao Yang et al.

PHYTOTHERAPY RESEARCH (2013)

Article Biochemistry & Molecular Biology

Iridoid-specific Glucosyltransferase from Gardenia jasminoides

Mai Nagatoshi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Plant Sciences

An evolutionary view of functional diversity in family 1 glycosyltransferases

Keiko Yonekura-Sakakibara et al.

PLANT JOURNAL (2011)

Review Biochemistry & Molecular Biology

Two rings in them all: The labdane-related diterpenoids

Reuben J. Peters

NATURAL PRODUCT REPORTS (2010)

Article Plant Sciences

Neoandrographolide from Andrographis paniculata as a Potential Natural Chemosensitizer

Petra H. Pfisterer et al.

PLANTA MEDICA (2010)

Review Biochemistry & Molecular Biology

Glycosyltransferases: Structures, functions, and mechanisms

L. L. Lairson et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2008)

Article Multidisciplinary Sciences

Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants

Melissa Brazier-Hicks et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Improved gateway binary vectors: High-performance vectors for creation of fusion constructs in Transgenic analysis of plants

Tsuyoshi Nakagawa et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2007)

Article Integrative & Complementary Medicine

In vivo and in vitro anti-inflammatory activities of neoandrographolide

Jun Liu et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2007)

Review Plant Sciences

Plant secondary metabolism glycosyltransferases: the emerging functional analysis

CMM Gachon et al.

TRENDS IN PLANT SCIENCE (2005)

Review Biochemistry & Molecular Biology

A class of plant glycosyltransferases involved in cellular homeostasis

EK Lim et al.

EMBO JOURNAL (2004)

Article Biochemistry & Molecular Biology

Flavonoids and andrographolides from Andrographis paniculata

YK Rao et al.

PHYTOCHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Crystal structure of p19 -: a universal suppressor of RNA silencing

DC Baulcombe et al.

TRENDS IN BIOCHEMICAL SCIENCES (2004)

Article Biochemical Research Methods

Virus-induced gene silencing in plants

R Lu et al.

METHODS (2003)

Article Biochemistry & Molecular Biology

Identification and biochemical characterization of an Arabidopsis indole-3-acetic acid glucosyltransferase

RG Jackson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)