4.6 Article

Alkaline intracellular pH (pHi) activates AMPK-mTORC2 signaling to promote cell survival during growth factor limitation

Related references

Note: Only part of the references are listed.
Review Physiology

REGULATION AND METABOLIC FUNCTIONS OF mTORC1 AND mTORC2

Angelia Szwed et al.

Summary: Cells metabolize nutrients for growth and proliferation, with mTOR playing a key role in integrating growth and metabolism through the protein complexes mTORC1 and mTORC2. Study of mTORC1 and mTORC2 has expanded our understanding of cellular metabolism regulation and functions.

PHYSIOLOGICAL REVIEWS (2021)

Review Cell Biology

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

Asier Gonzalez et al.

CELL METABOLISM (2020)

Article Biochemistry & Molecular Biology

The GATOR2?mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation

Allison Ho Kowalsky et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Review Cell Biology

mTOR at the nexus of nutrition, growth, ageing and disease

Grace Y. Liu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Oncology

Intracellular pH dynamics and charge-changing somatic mutations in cancer

Katharine A. White et al.

CANCER AND METASTASIS REVIEWS (2019)

Article Biochemistry & Molecular Biology

AMPK directly activates mTORC2 to promote cell survival during acute energetic stress

Dubek Kazyken et al.

SCIENCE SIGNALING (2019)

Article Cell Biology

A physiological drop in pH decreases mitochondrial respiration, and HDAC and Akt signaling, in L6 myocytes

Amanda J. Genders et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)

Article Biochemistry & Molecular Biology

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski et al.

MOLECULAR CELL (2019)

Review Cell Biology

mTOR as a central hub of nutrient signalling and cell growth

Joungmok Kim et al.

NATURE CELL BIOLOGY (2019)

Review Cell Biology

The lysosome as a cellular centre for signalling, metabolism and quality control

Rosalie E. Lawrence et al.

NATURE CELL BIOLOGY (2019)

Article Oncology

Oncogenic β-catenin mutations evade pH-regulated degradation

Bree K. Grillo-Hill et al.

MOLECULAR & CELLULAR ONCOLOGY (2019)

Article Biology

Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

Johanna Michl et al.

COMMUNICATIONS BIOLOGY (2019)

Review Cell Biology

AMPK: guardian of metabolism and mitochondrial homeostasis

Sebastien Herzig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Systems analysis of intracellular pH vulnerabilities for cancer therapy

Erez Persi et al.

NATURE COMMUNICATIONS (2018)

Article Cell Biology

beta-Catenin is a pH sensor with decreased stability at higher intracellular pH

Katharine A. White et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Cell Biology

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

Katharine A. White et al.

JOURNAL OF CELL SCIENCE (2017)

Review Biochemistry & Molecular Biology

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

Daniel Garcia et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

Haijuan Yang et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins

Katharine A. White et al.

SCIENCE SIGNALING (2017)

Article Biochemistry & Molecular Biology

Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins

Katharine A. White et al.

SCIENCE SIGNALING (2017)

Article Multidisciplinary Sciences

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling

Ahmad Merhi et al.

SCIENTIFIC REPORTS (2017)

Review Cell Biology

The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

Rachel L. Wolfson et al.

CELL METABOLISM (2017)

Review Biochemistry & Molecular Biology

AKT/PKB Signaling: Navigating the Network

Brendan D. Manning et al.

Review Cell Biology

mTORC1 signaling and the metabolic control of cell growth

Issam Ben-Sahra et al.

CURRENT OPINION IN CELL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Nutrient sensing and TOR signaling in yeast and mammals

Asier Gonzalez et al.

EMBO JOURNAL (2017)

Article Biochemistry & Molecular Biology

mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1

Joseph G. Moloughney et al.

MOLECULAR CELL (2016)

Review Cell Biology

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

D. Grahame Hardie et al.

TRENDS IN CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

A systems study reveals concurrent activation of AMPK and mTOR by amino acids

Piero Dalle Pezze et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Lysosomal recruitment of TSC2 is a universal response to cellular stress

Constantinos Demetriades et al.

NATURE COMMUNICATIONS (2016)

Review Biochemical Research Methods

A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways

Ana P. Gomes et al.

CURRENT OPINION IN BIOTECHNOLOGY (2015)

Article Oncology

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

Pengda Liu et al.

CANCER DISCOVERY (2015)

Article Biochemistry & Molecular Biology

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

Constantinos Demetriades et al.

Review Cell Biology

Growing knowledge of the mTOR signaling network

Kezhen Huang et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)

Editorial Material Oncology

The LKB1-AMPK Pathway-Friend or Foe in Cancer?

D. Grahame Hardie

CANCER CELL (2013)

Editorial Material Multidisciplinary Sciences

CANCER METABOLISM Tumour friend or foe

Robert U. Svensson et al.

NATURE (2012)

Article Multidisciplinary Sciences

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Dudley W. Lamming et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling

Irantzu Tato et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Dana M. Gwinn et al.

MOLECULAR CELL (2008)

Article Cell Biology

Regulation of TORC1 by Rag GTPases in nutrient response

Eunjung Kim et al.

NATURE CELL BIOLOGY (2008)

Article Multidisciplinary Sciences

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Yasemin Sancak et al.

SCIENCE (2008)

Article Biochemistry & Molecular Biology

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

XM Long et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Rheb binds and regulates the mTOR kinase

X Long et al.

CURRENT BIOLOGY (2005)

Article Multidisciplinary Sciences

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

DD Sarbassov et al.

SCIENCE (2005)