Journal
FOOD CHEMISTRY
Volume 190, Issue -, Pages 1050-1055Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2015.06.081
Keywords
Ipriflavone; Trans-glycosylated rutin; Water sorption; Dissolution rate; Surface tension
Funding
- JSPS KAKENHI (Tokyo, Japan) [25504018]
- Grants-in-Aid for Scientific Research [25504018] Funding Source: KAKEN
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The improvement in the solubility and dissolution rate may promote a superior absorption property towards the human body. The spray-dried powders (SDPs) of ipriflavone, which was used as a model hydrophobic flavone, with trans-glycosylated rutin (Rutin-G) showed the highest solubilizing effect of ipriflavone among three types of trans-glycosylated food additives. The SDPs of ipriflavone with Rutin-G have both a significant higher dissolution rate and solubility enhancement of ipriflavone. This spray-dried formulation of ipriflavone with Rutin-G exhibited a low hygroscopicity as a critical factor in product preservation. In addition, an improvement in the oral absorption of ipriflavone was achieved by means of preparing composite particles of ipriflavone/Rutin-G via spray drying, indicating a 4.3-fold increase in the area under the plasma concentration time curve compared with that of untreated ipriflavone. These phenomena could be applicable to food ingredients involving hydrophobic flavones for producing healthy food with a high quality. (C) 2015 Elsevier Ltd. All rights reserved.
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