Journal
JOURNAL OF BACTERIOLOGY
Volume 203, Issue 21, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00383-21
Keywords
human gut microbiota; Bacteroidetes; genetic regulation; polysaccharides; capsule; Bacteroides; capsular polysaccharide; regulatory RNA
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Funding
- NIDDK NIH HHS [R01 DK118024, K01 DK084214] Funding Source: Medline
- NIH HHS [DK084214, DK118024] Funding Source: Medline
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Recent studies have identified a novel family of RNA-binding proteins in Bacteroides thetaiotaomicron that play a crucial role in regulating genes involved in carbohydrate utilization and capsule expression.
The last two decades have seen numerous studies connecting physiological behaviors in Bacteroides-including polysaccharide degradation and capsule production-with elements of global regulation, but a complete model is still elusive. A new study by Adams et al. in this issue of the Journal of Bacteriology reveals another layer of regulation by describing a novel family of RNA-binding proteins in Bacteroides thetaiotaomicron that modify expression of genes involved in carbohydrate utilization and capsule expression, among others (A. N. D. Adams, M. S. Azam, Z. A. Costliow, X. Ma, et al., J Bacteriol 203: e00217-21, 2021, https://doi.org/10.1128/JB.00217-21).
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