Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 24, Issue 5, Pages 483-489Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2021.1939311
Keywords
Dictamnus dasycarpus; alkaloid; furoquinoline; antimicrobial activity
Funding
- Drug Innovation Major Project of China [2018ZX09711-001-001-001, 2018ZX09711-001-001-003]
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Two new furoquinoline alkaloids, named 1'-oxo-isoplatydesmine (1) and demethoxyacrophylline (2), along with 11 known alkaloids (3-13), were isolated from the root bark of Dictamnus dasycarpus Turcz. Compounds 3-5 exhibited moderate inhibitory activities against certain bacteria, indicating their potential for traditional treatment of skin diseases.
Two new furoquinoline alkaloids, named 1'-oxo-isoplatydesmine (1) and demethoxyacrophylline (2), as well as 11 known alkaloids (3-13) were isolated from the root bark of Dictamnus dasycarpus Turcz. The structures of 1 and 2 were established by detailed spectroscopic elucidation, such as 1 D & 2 D NMR and HRMS, etc. The unexpected autoracemization of 1 was discussed based on the stereochemistry of reported dihydrofuroquinolines. Compounds 3-5 exhibited moderate inhibitory activities against Bacillus subtilis, Candida albicans, and Pseudomonas aeruginosa with MICs 32-64 mu g/ml, revealing the active principles of D. dasycarpus for treating skin diseases in its traditional usage.
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