Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 24, Issue 3, Pages 278-289Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2021.1949302
Keywords
Quercetin; ischemic stroke; blood-brain barrier; Sirt1; oxidative stress
Funding
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-3-007, 2017-I2M-1-010]
- Major Scientific and Technological Special Project for Significant New Drug Creation [2018ZX09711001-003-005]
- National Natural Science Foundation of China [81102444, 82073863, 82004071]
- China Scholarship Council [201808110107]
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The study demonstrated that quercetin has neuroprotective effects by protecting the BBB in MCAO rats through the Sirt1 signaling pathway, reducing neurological deficits and cerebral infarct volume.
The purpose of the present study was to examine the protective action and mechanisms of quercetin on the blood-brain barrier (BBB) in rats subjected to transient middle cerebral artery occlusion (tMCAO) and reperfusion. Quercetin (10, 30, 50 mg/kg) was intraperitoneally administered at the onset of reperfusion. The results showed that quercetin significantly reduced cerebral infarct volume, neurological deficit, BBB permeability and ROS generation via Sirt1/Nrf2/HO-1 signaling pathway. Moreover, EX527, a selective inhibitor of Sirt1, reversed these neuroprotective effects. Our findings indicate that quercetin has neuroprotective effects against cerebral ischemia-reperfusion injury by protecting BBB through Sirt1 signaling pathway in MCAO rats.
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