Journal
JOURNAL OF APPLIED SPECTROSCOPY
Volume 88, Issue 4, Pages 882-886Publisher
SPRINGER
DOI: 10.1007/s10812-021-01254-9
Keywords
erlotinib hydrochloride; UV spectrometric; zero order; AUC; anticancer
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Two different UV spectrophotometric methods were developed for the estimation of erlotinib hydrochloride, showing good linearity, reproducibility, and accuracy in the concentration range of 10-70 μg/mL. The limit of detection and quantification were found to be 1.16, 3.51, and 21.41, 64.90 μg/mL, respectively, for both methods.
Two different simple, accurate, and precise UV spectrophotometric methods have been developed for the estimation of erlotinib hydrochloride in bulk and tablet forms by the zero-order (method I) and the zero-order AUC (method II). The drug was dissolved in a phosphate buffer solution (pH 7.4), and at 228.20 nm the zero-order (method I) and at 224.20-230.20 nm the zero-order AUC (method II) were developed. For both methods, erlotinib has linearity in the concentration range 10-70 mu g/mL, with a correlation coefficient R-2 > 0.99. Both methods showed good reproducibility and recovery with %RSD less than 2 and an accuracy of 98.54-101.39 and 98.08-99.83%, respectively. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 1.16, 3.51, and 21.41, 64.90 mu g/mL, respectively, for both methods.
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