Journal
FOOD CHEMISTRY
Volume 190, Issue -, Pages 529-536Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2015.06.003
Keywords
Pharmaceuticals; Drugs; Diazepam; Diphenhydramine; Edible fish; Grocery stores; GC-MS
Funding
- College of Arts and Sciences
- Northwest Missouri State University
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Occurrences of pharmaceuticals are evident in aquatic organisms. A reproducible gas chromatography-. mass spectrometry (GC-MS) method using selected ion monitoring (SIM) has been used to determine the anti-histamine diphenhydramine (DPH), anti-anxiety diazepam (DZP), anti-seizure carbamazepine (CZP) drugs and their metabolites in grocery stores fish that were homogenized, extracted, pre-concentrated, cleaned up, and examined. Identifications of the compounds in extracts were obtained by comparing similar mass spectral features and retention properties with standards. Among nine frequently detected drugs, only DPH and DZP were observed and ranged from 0.61 to 6.21 and 1.99 to 16.57 ng/g, respectively, in fourteen fish species. These concentration values were lower than the environmental fish. Mean spike recoveries of analytes exceeded 75% with relative standard deviations (RSD) < 10%. The statistically-derived method detection limits (MDLs) for nine compounds ranged from 0.13 to 5.56 ng/g. Average surrogate recoveries were 80-85% with 4-9% RSD. (C) 2015 Elsevier Ltd. All rights reserved.
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