Journal
JOURNAL OF ANTIBIOTICS
Volume 74, Issue 11, Pages 821-824Publisher
SPRINGERNATURE
DOI: 10.1038/s41429-021-00464-9
Keywords
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Funding
- Guangxi Young and Middle-aged University Teachers' Scientific Research Ability Enhancement Project [2021KY0318]
- Initial Scientific Research Foundation of Introduced Doctors in 2020 of Guangxi University of Chinese Medicine [2020BS024]
- Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine [2021004]
- Special Fund for Bagui Scholars of Guangxi [05019055]
- Guangxi Province Natural Science Foundation of Innovative Research Team Project [2020GXNSFGA297002]
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A new benzophenone derivative and a new benzophenone natural product, along with two known compounds, were isolated from the endophytic fungus Penicillium sp. collected in the South China Sea. The new compounds exhibited moderate antibacterial activities against methicillin-resistant Staphylococcus aureus.
One new benzophenone derivative, named penibenzophenone C (1), and a new benzophenone natural product, neamed penibenzophenone D (2), together with two known compounds (3, 4) were isolated from the EtOAc extract of the endophytic fungus Penicillium sp. isolated from the mangrove Acanthus ilicifolius L. collected in the South China Sea. The structures of 1-4 were elucidated by extensive NMR spectral interpretation and MS data. The new compounds 1 and 2 showed moderate antibacterial activities against methicillin-resistant Staphylococcus aureus with the MIC values of 3.12 and 6.25 mu g ml(-1), respectively.
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