4.5 Review

The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article

Journal

JOURNAL OF ANTIBIOTICS
Volume 75, Issue 2, Pages 122-122

Publisher

SPRINGERNATURE
DOI: 10.1038/s41429-021-00430-5

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This article discusses the mechanism of action of Ivermectin against SARS-CoV-2 and its potential in preventing complications, summarizing the available literature on the drug over the years.
Considering the urgency of the ongoing COVID-19 pandemic, detection of various new mutant strains and future potential re-emergence of novel coronaviruses, repurposing of approved drugs such as Ivermectin could be worthy of attention. This evidence-based review article aims to discuss the mechanism of action of ivermectin against SARS-CoV-2 and summarizing the available literature over the years. A schematic of the key cellular and biomolecular interactions between Ivermectin, host cell, and SARS-CoV-2 in COVID-19 pathogenesis and prevention of complications have been proposed.

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