Journal
JOURNAL OF ANTIBIOTICS
Volume 74, Issue 8, Pages 485-495Publisher
SPRINGERNATURE
DOI: 10.1038/s41429-021-00429-y
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Funding
- JSPS KAKENHI [JP17H06412, JP20K05858]
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Six new 11-mer peptaibols named zealpeptaibolins, A - F, were isolated from soil fungus Trichoderma sp. RK10-F026, showing that peptaibol production is dependent on culture conditions. Among these, zealpeptaibolin F exhibited the highest cytotoxicity against K562 leukemia cells.
Six new 11-mer peptaibols designed as zealpeptaibolins, A - F were isolated from the soil fungus, Trichoderma sp. RK10-F026, based on the principal component analysis of the MS data from five different culture compositions. Previously, 20-mer peptaibols from the same fungal strain were identified; 11-mer peptaibols in contrast were discovered from a different culture condition, signifying peptaibol production was culture condition-dependent. These peptaibols contained three Aib-Pro motifs in the sequence. The structures were established by NMR and HR-MS experiments including detailed MS/MS fragmentations. The absolute configurations were determined by Marfey's analysis. Zealpeptaibolin F exhibited the strongest cytotoxicity toward K562 leukemia cells with an IC50 value of 0.91 mu M.
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