Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 92, Issue -, Pages 217-223Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2016.04.011
Keywords
Fipronil; Phenylpyrazole; Lipid metabolism; Adipogenesis; AMPK alpha
Categories
Funding
- China Scholarship Council
Ask authors/readers for more resources
Emerging evidence suggests that organochlorine, organophosphorus and neonicotinoid insecticide exposure may be linked to the development of obesity and type 2 diabetes. However, there is no knowledge of the potential influence of fipronil, which belongs to the phenylpyrazole chemical family, on obesity. Thus, the goal of this study was to determine the role of fipronil in adipogenesis using 3T3-L1 adipocytes. Fipronil treatment, at 10 mu M, increased fat accumulation in 3T3-L1 adipocytes as well as promoted key regulators of adipocyte differentiation (CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma-gamma), and key regulators of lipogenesis (acetyl-CoA carboxylase and fatty acid synthase). The activation of AMPK alpha with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) abolished effects of fipronil on increased adipogenesis. These results suggest that fipronil alters adipogenesis and results in increased lipid accumulation through a AMPK alpha-mediated pathway. (C) 2016 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available