Journal
JOURNAL OF ANATOMY
Volume 239, Issue 4, Pages 801-828Publisher
WILEY
DOI: 10.1111/joa.13459
Keywords
balance; inner ear; otocysts; otoliths; saccule; semi‐ circular canals; signaling pathways; utricle; vertigo; vestibular apparatus; vestibular system; vestibulocochlear nerve
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Funding
- National Science and Engineering Research Council of Canada
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The vertebrate inner ear is a crucial sensory organ responsible for perceiving sound and body motion. Recent research has started to uncover the complex developmental program and inner ear apparatuses related to vestibular function. These studies have identified genes involved in inner ear development and model syndromes, providing potential treatments for individuals with vestibular disorders.
The vertebrate inner ear is a labyrinthine sensory organ responsible for perceiving sound and body motion. While a great deal of research has been invested in understanding the auditory system, a growing body of work has begun to delineate the complex developmental program behind the apparatuses of the inner ear involved with vestibular function. These animal studies have helped identify genes involved in inner ear development and model syndromes known to include vestibular dysfunction, paving the way for generating treatments for people suffering from these disorders. This review will provide an overview of known inner ear anatomy and function and summarize the exciting discoveries behind inner ear development and the evolution of its vestibular apparatuses.
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