4.5 Article

Mild Microglial Responses in the Cortex and Perivascular Macrophage Infiltration in Subcortical White Matter in Dogs with Age-Related Dementia Modelling Prodromal Alzheimer's Disease

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer's disease and other tauopathies

Ajantha Abey et al.

Summary: Aged community dogs with Canine Cognitive Dysfunction (CCD) exhibit similarities to human dementia, particularly in terms of tau pathology, indicating that CCD could serve as a valuable ecological model for Alzheimer's Disease (AD). Research shows concordance in regional distribution of tauopathy between CCD and AD, with a focus on tau protein labeling in the brain's neural circuitry.

BRAIN PATHOLOGY (2021)

Article Clinical Neurology

Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation

Luis Aragao Gomes et al.

Summary: In the study, tau pathology initiation in Alzheimer's disease was found to follow similar processes when propagating into previously unaffected regions, with the appearance of IC- and IN-tau being the initial tau lesions. This suggests that these lesions may play a crucial role in the development of Alzheimer's disease, even in cases classified as nonAD.

ACTA NEUROPATHOLOGICA (2021)

Article Clinical Neurology

The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer's disease

Baayla D. C. Boon et al.

ACTA NEUROPATHOLOGICA (2020)

Review Geriatrics & Gerontology

Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities

Anne-Laure Hemonnot et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model

Elizabeth Spangenberg et al.

NATURE COMMUNICATIONS (2019)

Article Clinical Neurology

Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk

Dervis A. Salih et al.

BRAIN COMMUNICATIONS (2019)

Review Cell Biology

Microglia in Alzheimer's disease

David V. Hansen et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Neurosciences

Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson's Disease?

Elzbieta Janda et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Review Neurosciences

White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes

Sara E. Nasrabady et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)

Article Neurosciences

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer's disease

Maria Luisa Moro et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)

Article Clinical Neurology

White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease

Miguel Angel Araque Caballero et al.

BRAIN (2018)

Article Neurosciences

Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer's disease

Ruohe Zhao et al.

MOLECULAR NEURODEGENERATION (2017)

Article Neurosciences

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

Thais F. Galatro et al.

NATURE NEUROSCIENCE (2017)

Article Neurosciences

Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain

Divya Raj et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

Article Neurosciences

The Canine (Dog) Model of Human Aging and Disease: Dietary, Environmental and Immunotherapy Approaches

Carl W. Cotman et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Article Cardiac & Cardiovascular Systems

Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides

Laibaik Park et al.

CIRCULATION RESEARCH (2017)

Article Biochemistry & Molecular Biology

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Hadas Keren-Shaul et al.

Article Veterinary Sciences

The Relation between canine cognitive dysfunction and age-related brain lesions

Makiko Ozawa et al.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2016)

Article Immunology

Origin, fate and dynamics of macrophages at central nervous system interfaces

Tobias Goldmann et al.

NATURE IMMUNOLOGY (2016)

Article Immunology

Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice

Alicia A. Babcock et al.

BRAIN BEHAVIOR AND IMMUNITY (2015)

Article Clinical Neurology

Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines

Franziska Schmidt et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2015)

Review Clinical Neurology

Neuroinflammation in Alzheimer's disease

Michael T. Heneka et al.

LANCET NEUROLOGY (2015)

Article Clinical Neurology

Amyloid-β Immunotherapy Reduces Amyloid Plaques and Astroglial Reaction in Aged Domestic Dogs

Maria Neus Bosch et al.

NEURODEGENERATIVE DISEASES (2015)

Article Multidisciplinary Sciences

Fibrillar Amyloid Plaque Formation Precedes Microglial Activation

Christian K. E. Jung et al.

PLOS ONE (2015)

Article Clinical Neurology

Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease

Alberto Serrano-Pozo et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2013)

Article Genetics & Heredity

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert et al.

NATURE GENETICS (2013)

Review Clinical Neurology

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Peter T. Nelson et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2012)

Article Multidisciplinary Sciences

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

Justin M. Nussbaum et al.

NATURE (2012)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Article Geriatrics & Gerontology

Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines

Viorela Pop et al.

NEUROBIOLOGY OF AGING (2012)

Article Pathology

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

Alberto Serrano-Pozo et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Article Medicine, Research & Experimental

Neuropathological Alterations in Alzheimer Disease

Alberto Serrano-Pozo et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)

Article Neurosciences

Microglia Mediate the Clearance of Soluble Aβ through Fluid Phase Macropinocytosis

Shweta Mandrekar et al.

JOURNAL OF NEUROSCIENCE (2009)

Review Biochemistry & Molecular Biology

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

C. -X. Gong et al.

CURRENT MEDICINAL CHEMISTRY (2008)

Article Neurosciences

Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice

Suzanne E. Hickman et al.

JOURNAL OF NEUROSCIENCE (2008)

Review Cell Biology

Immunohistochemical markers for quantitative studies of neurons and glia in human neocortex

Lise Lyck et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2008)

Article Neurosciences

Microglial cell population dynamics in the injured adult central nervous system

R Ladeby et al.

BRAIN RESEARCH REVIEWS (2005)

Article Geriatrics & Gerontology

Vascular and parenchymal Aβ deposition in the aging dog:: correlation with behavior

MA Colle et al.

NEUROBIOLOGY OF AGING (2000)

Article Geriatrics & Gerontology

Region-specific age at onset of beta-amyloid in dogs

E Head et al.

NEUROBIOLOGY OF AGING (2000)