Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 90, Issue -, Pages 181-187Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2016.02.014
Keywords
Gelidium amansii; Edible seaweed; Anti-obesity; High fat diet; Adipogenesis
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Funding
- Ministry of Education (MOE)
- National Research Foundation of Korea (NRF) through the Human Resource Training Project for Regional Innovation [NRF-2012H1B8A2025863]
- National Research Foundation of Korea [2012H1B8A2025863] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The popular edible seaweed, Gelidium amansii is broadly used as food worldwide. To determine whether G. amansii extract (GAE) has protective effects on obesity, mice fed a high-fat diet (HFD) treated with GAE (1 and 3 %) were studied. After 12 weeks of GAE treatment, body weight was greatly decreased in mice fed a high-fat diet. This effect could be due to decreased adipogenesis, as evidenced by the fact that GAE suppressed adipogenic gene expression in adipocytes. In addition, blood glucose and serum insulin levels were reduced by GAE treatment in mice fed a high-fat diet, suggesting improvement in glucose metabolism. GAE supplementation also led to a significant decrease in total cholesterol and triglyceride levels. These data are further confirmed by H&E staining. Our findings indicate that Gelidium amansii prevents against the development of diet-induced obesity, and further implicate that GAE supplementation could be the therapeutical option for treatment of metabolic disorder such as obesity. (C) 2016 Elsevier Ltd. All rights reserved.
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