Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 69, Issue 23, Pages 6423-6430Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c07538
Keywords
nicotinic acid derivatives; herbicidal activities; synthesis; natural products
Funding
- Zhejiang Provincial Natural Science Foundation of China [LY19C140002]
- Research Fund of Department of Education of Zhejiang Province [Y201941832]
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Nicotinic acid, also known as niacin, is a natural product found in plants and animals. In this study, N-(arylmethoxy)-2-chloronicotinamides were designed and synthesized as potential herbicides. Some of these compounds showed promising herbicidal activity and could be used for the development of new herbicides against monocotyledonous weeds.
Nicotinic acid, also known as niacin, is a natural product, which is widely found in plants and animals. To discover novel natural-product-based herbicides, a series of N-(arylmethoxy)-2-chloronicotinamides were designed and synthesized. Some of the new N-(arylmethoxy)-2-chloronicotinamides exhibited excellent herbicidal activity against Agrostis stolonifera (bentgrass) at 100 mu M. Compound 5f (2-chloro-N-((3,4-dichlorobenzyl)oxy)nicotinamide) possessed excellent herbicidal activity against Lemna paucicostata (duckweed), with an IC50 value of 7.8 mu M, whereas the commercial herbicides clomazone and propanil had values of 125 and 2 mu M, respectively. The structure-activity relationships reported in this paper could be used for the development of new herbicides against monocotyledonous weeds.
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