Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 69, Issue 23, Pages 6510-6523Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c01070
Keywords
Lactobacillus plantarum ZJ316; Helicobacter pylori ZJC03; probiotics; inflammatory effects; gastric microbiota
Funding
- Major Program of Natural Science Foundation of Zhejiang Province [U20A2066]
- Chinese Academy of Engineering Academy-Locality Cooperation Project [2019-ZJ-JS-02]
- Natural Science Foundation of Zhejiang Province [LY16C200002, LQ18C200004]
- Food Science and Engineering.the most important discipline of Zhejiang Province [2017SIAR202]
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The study found that Lactobacillus plantarum ZJ316 had significant anti-H. pylori ability, decreased IFN-gamma and IL-6 levels, increased IL-10 levels, repaired mucosal damage, and reduced the abundance of H. pylori. Different microbial families were more prevalent in the prevention and treatment groups, indicating that L. plantarum ZJ316 could be a potential candidate for the prevention and treatment of H. pylori-induced gastritis by modulating the gastric microbiota and reducing mucosal inflammation.
Helicobacter pylori is a highly prevalent human-specific pathogen that causes various gastric diseases. In the present study, Lactobacillus plantarum ZJ316, which could survive well in simulated gastrointestinal conditions, was found to have significant anti-H. pylori ability. Animal assays revealed that L. plantarum ZJ316 had preventive and therapeutic effects on H. pylori-induced gastritis. L. plantarum ZJ316 significantly decreased interferon gamma (IFN-gamma) and interleukin 6 (IL-6) levels, increased the IL-10 level, and repaired mucosal damage. Moreover, 16S rRNA gene sequencing revealed that the relative abundance of H. pylori could be significantly reduced by L. plantarum ZJ316 administration. Members of the families Dehalobacteriaceae and Geodermatophilaceae were more prevalent in the prevention group, while Lactobacillaceae and Actinomycetaceae were more prevalent in the treatment group. These results indicate that L. plantarum ZJ316 serves as a potential candidate for the prevention and treatment of H. pylori-induced gastritis by regulating the gastric microbiota and reducing mucosal inflammation.
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