Journal
IUBMB LIFE
Volume 74, Issue 1, Pages 8-23Publisher
WILEY
DOI: 10.1002/iub.2529
Keywords
adaptive response; biphasic dose response; carcinogens; dose response; hormesis; ionizing radiation; LNT; neuroprotection; Nrf2; risk assessment
Categories
Funding
- US Air Force [AFOSR FA9550-19-1-0413]
- Exxon Mobil Foundation [S18200000000256]
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Hormesis is a fundamental evolutionary adaptive strategy that can decelerate common age-related health problems. Incorporating hormetic-based lifestyle options within the population would have profound positive impacts on public health.
This article tells the story of hormesis from its conceptual and experimental origins, its dismissal by the scientific and medical communities in the first half of the 20th century, and its rediscovery over the past several decades to be a fundamental evolutionary adaptive strategy. The upregulation of hormetic adaptive mechanisms has the capacity to decelerate the onset and reduce the severity of a broad spectrum of common age-related health, behavioral, and performance decrements and debilitating diseases, thereby significantly enhancing the human health span. Incorporation of hormetic-based lifestyle options within the human population would have profoundly positive impacts on the public health, significantly reducing health care costs.
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