Journal
INTERNATIONAL REVIEWS OF IMMUNOLOGY
Volume 42, Issue 1, Pages 1-25Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/08830185.2021.1964498
Keywords
-
Categories
Ask authors/readers for more resources
B cells play a crucial role in adaptive immunity, involving antigen presentation, antibody production, and cytokine secretion. Transcription factors, cytokines, and epigenetic regulations are involved in B cell development, and dysregulation of these processes is associated with autoimmune diseases.
B cells play a crucial role in antigen presentation, antibody production and pro-/anti-inflammatory cytokine secretion in adaptive immunity. Several translational factors including transcription factors and cytokines participate in the regulation of B cell development, with the cooperation of epigenetic regulations. Autoimmune diseases are generally characterized with autoreactive B cells and high-level pathogenic autoantibodies. The success of B cell depletion therapy in mouse model and clinical trials has proven the role of B cells in pathogenesis of autoimmune diseases. The failure of B cell tolerance in immune checkpoints results in accumulated autoreactive naive B (B-N) cells with aberrant B cell receptor signaling and dysregulated B cell response, contributing to self-antibody-mediated autoimmune reaction. Dysregulation of translational factors and epigenetic alterations in B cells has been demonstrated to correlate with aberrant B cell compartment in autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, primary Sjogren's syndrome, multiple sclerosis, diabetes mellitus and pemphigus. This review is intended to summarize the interaction of translational factors and epigenetic regulations that are involved with development and differentiation of B cells, and the mechanism of dysregulation in the pathogenesis of autoimmune diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available