4.3 Review

The ubiquitous role of spleen tyrosine kinase (Syk) in gut diseases: From mucosal immunity to targeted therapy

Related references

Note: Only part of the references are listed.
Article Oncology

CCL4-mediated targeting of spleen tyrosine kinase (Syk) inhibitor using nanoparticles alleviates inflammatory bowel disease

Wenbin Gong et al.

Summary: Inflammatory bowel disease (IBD) is a global disease with varied treatment responses, thus novel therapeutic approaches are needed. This study found that using Syk inhibitor piceatannol and poly(lactic-co-glycolic acid) nanoparticles conjugated with chemokine C-C motif ligand 4 effectively treated IBD.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Multidisciplinary Sciences

Preliminary exploration of the potential of spliceosome-associated protein 130 for predicting disease severity in Crohn's disease

Wenbin Gong et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2020)

Review Gastroenterology & Hepatology

Role of spleen tyrosine kinase in liver diseases

Dhadhang Wahyu Kurniawan et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

Review Immunology

Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases

Kata P. Szilveszter et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Agriculture, Multidisciplinary

Short-Chain Fatty Acids Suppress Inflammatory Reactions in Caco-2 Cells and Mouse Colons

Tran Van Hung et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

Review Nutrition & Dietetics

Microbiome and intestinal ischemia/reperfusion injury

Yuji Nadatani et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2018)

Article Gastroenterology & Hepatology

TNF-anti-TNF Immune Complexes Inhibit IL-12/IL-23 Secretion by Inflammatory Macrophages via an Fc-dependent Mechanism

Felicia M. Bloemendaal et al.

JOURNAL OF CROHNS & COLITIS (2018)

Review Immunology

Spleen Tyrosine Kinase as a Target Therapy for Pseudomonas aeruginosa Infection

Alaa Alhazmi

JOURNAL OF INNATE IMMUNITY (2018)

Article Multidisciplinary Sciences

CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi

Irina Leonardi et al.

SCIENCE (2018)

Review Immunology

The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

Joannie M. Allaire et al.

TRENDS IN IMMUNOLOGY (2018)

Review Immunology

Mast Cells as Drivers of Disease and Therapeutic Targets

Frank Siebenhaar et al.

TRENDS IN IMMUNOLOGY (2018)

Review Immunology

The interaction of Human Pathogenic Fungi with C-Type Lectin Receptors

Surabhi Goyal et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Immunology

Developmental and Functional Heterogeneity of Monocytes

Martin Guilliams et al.

IMMUNITY (2018)

Review Immunology

Origin, Differentiation, and Function of Intestinal Macrophages

Calum C. Bain et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Chemistry, Medicinal

Role of Reactive Oxygen Species (ROS) in Therapeutics and Drug Resistance in Cancer and Bacteria

Allimuthu T. Dharmaraja

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Immunology

Diversity and functions of intestinal mononuclear phagocytes

T. Joeris et al.

MUCOSAL IMMUNOLOGY (2017)

Review Immunology

Dendritic cell migration in health and disease

Tim Worbs et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Gastroenterology & Hepatology

The role of mast cells in functional GI disorders

Mira M. Wouters et al.

Article Microbiology

Immunological Consequences of Intestinal Fungal Dysbiosis

Matthew L. Wheeler et al.

CELL HOST & MICROBE (2016)

Review Multidisciplinary Sciences

The microbiota in adaptive immune homeostasis and disease

Kenya Honda et al.

NATURE (2016)

Review Multidisciplinary Sciences

Interactions between the microbiota and pathogenic bacteria in the gut

Andreas J. Baumler et al.

NATURE (2016)

Review Medicine, General & Internal

The Human Intestinal Microbiome in Health and Disease

Susan V. Lynch et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, General & Internal

Irritable bowel syndrome

Paul Enck et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Review Cell Biology

The intestinal epithelium as guardian of gut barrier integrity

Kaiyi Zhang et al.

CELLULAR MICROBIOLOGY (2015)

Article Gastroenterology & Hepatology

The Syk Inhibitor Fostamatinib Decreases the Severity of Colonic Mucosal Damage in a Rodent Model of Colitis

Guray Can et al.

JOURNAL OF CROHNS & COLITIS (2015)

Article Chemistry, Medicinal

Overcoming Mutagenicity and Ion Channel Activity: Optimization of Selective Spleen Tyrosine Kinase Inhibitors

J. Michael Ellis et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Multidisciplinary Sciences

Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium

Yoji Murata et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Immunology

Human intestinal epithelial cells respond to β-glucans via Dectin-1 and Syk

Sarit Cohen-Kedar et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2014)

Review Immunology

Intestinal dendritic cells in the regulation of mucosal immunity

Vasileios Bekiaris et al.

IMMUNOLOGICAL REVIEWS (2014)

Review Pharmacology & Pharmacy

Getting Syk: spleen tyrosine kinase as a therapeutic target

Robert L. Geahlen

TRENDS IN PHARMACOLOGICAL SCIENCES (2014)

Article Gastroenterology & Hepatology

Inhibition of spleen tyrosine kinase as treatment of postoperative ileus

Sjoerd H. W. van Bree et al.

Article Gastroenterology & Hepatology

Mucosal Immune Cell Numbers and Visceral Sensitivity in Patients With Irritable Bowel Syndrome: Is There Any Relationship

Breg Braak et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2012)

Review Immunology

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

David Sancho et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)

Article Chemistry, Medicinal

Rational Design of Highly Selective Spleen Tyrosine Kinase Inhibitors

Matthew C. Lucas et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Review Immunology

Monocyte recruitment during infection and inflammation

Chao Shi et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Article Gastroenterology & Hepatology

Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion

Omer Nuri Pamuk et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Review Immunology

The SYK tyrosine kinase: a crucial player in diverse biological functions

Attila Mocsai et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Review Immunology

Autoinhibition and adapter function of Syk

Yogesh Kulathu et al.

IMMUNOLOGICAL REVIEWS (2009)