Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 71, Issue 16, Pages 1240-1251Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2021.1960341
Keywords
Antibacterial; bilayer wound dressing materials; controlled drug delivery; MTT assay
Categories
Funding
- Scientific Projects Coordination Unit of Hitit University [MUH19001.19.004]
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In summary, a novel bilayer wound dressing based on gelatin and gellan gum was developed in this research, which showed antibiotic release capability in the upper layer and good cytocompatibility with fibroblast cells.
Bilayer wound dressing systems consisting of various biopolymers have been preferred in biomedical applications due to its enhanced advantages in comparison with conventional systems. The aim of this research was to develop a novel bilayer wound dressing based on gelatin (G) and gellan gum (GG). The bilayer was composed of an upper layer impregnated with antibiotic drug sodium ampicillin and a drug-free lower sponge layer. The bilayer hydrogels were characterized by FTIR, TGA, DSC and SEM analyses including swelling behaviors and hydrolytic degradation tests. To achieve faster healing of the wound by prevention of the bacterial infection, the bilayer hydrogels were developed as antibiotic-releasing vehicles. Herein, release study of sodium ampicillin was performed in PBS to simulate the physiological micro-environment. Additionally, cyto-compatibility tests of L929 fibroblast cells showed the high proliferation and survival through drug-loaded GG and G hydrogels (GG-G-D) after 24h, 48h and 72h incubation. This novel GG-G bilayer hydrogel could be a good candidate as wound dressing.
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