Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 602, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120635
Keywords
Poloxamer; Infectious diseases; Vaginal application; Drug delivery; Biological behavior
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
- Sao Paulo Research Foundation (FAPESP, Brazil) [2019/251257]
- National Council for Scientific and Technological Development (CNPq, Brazil) [408244/20186, 465687/20148]
- FAPESP [2014/509282]
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Infectious diseases related to the vagina pose challenges due to incomplete treatment and drug resistance. New treatment strategies, such as vaginal drug delivery, are desirable, although patient discomfort may be a limitation. Stimuli-sensitive poloxamer-based drug delivery systems show promise for improving treatment outcomes.
Infectious diseases related to the vagina include diseases caused by the imbalance of the vaginal flora and by sexually transmitted infections. Some of these present themselves as a public health problem due to the lack of efficient treatment that leads to their complete cure, and others due to the growing resistance to drugs used in therapy. In this sense, new treatment strategies are desirable, with vaginal administration rout being a great choice since can bypass first-pass metabolism and decrease drug interactions and adverse effects. However, it is worth highlighting limitations related to patient's discomfort at application time. Thereby, the use of poloxamerbased drug delivery systems is desirable due its stimuli-sensitive characteristic. Therefore, the present review reports a brief overview of poloxamer properties, biological behavior and advances in poloxamer applications in controlled drug release systems for infectious diseases related to the vagina treatment and prevention.
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