Related references
Note: Only part of the references are listed.Structural basis for stabilization of human telomeric G-quadruplex [d-(TTAGGGT)]4 by anticancer drug adriamycin
Ritu Barthwal et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)
Curcumin analogs exhibit anti-cancer activity by selectively targeting G-quadruplex forming c-myc promoter sequence
Nirali Pandya et al.
BIOCHIMIE (2021)
Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer
Liang Zeng et al.
BIOORGANIC CHEMISTRY (2021)
MYC as a target for cancer treatment
Michael J. Duffy et al.
CANCER TREATMENT REVIEWS (2021)
Recent Update on Targeting c-MYC G-Quadruplexes by Small Molecules for Anticancer Therapeutics
Ritapa Chaudhuri et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
The solution structures of higher-order human telomere G-quadruplex multimers
Robert C. Monsen et al.
NUCLEIC ACIDS RESEARCH (2021)
G-Quadruplexes in RNA Biology: Recent Advances and Future Directions
Leila Dumas et al.
TRENDS IN BIOCHEMICAL SCIENCES (2021)
G-quadruplexes: a promising target for cancer therapy
Nils Kosiol et al.
MOLECULAR CANCER (2021)
Recent Developments in Small-Molecule Ligands of Medicinal Relevance for Harnessing the Anticancer Potential of G-Quadruplexes
Loukiani Savva et al.
MOLECULES (2021)
G-quadruplex binding properties of a potent PARP-1 inhibitor derived from 7-azaindole-1-carboxamide
Sabrina Dallavalle et al.
SCIENTIFIC REPORTS (2021)
New insight into G-quadruplexes; diagnosis application in cancer
Kosar Shahsavar et al.
ANALYTICAL BIOCHEMISTRY (2021)
The role of epithelial-mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
Jihye Seo et al.
ARCHIVES OF PHARMACAL RESEARCH (2021)
Long non-coding RNAs at work on telomeres: Functions and implications in cancer therapy
Kavita Gala et al.
CANCER LETTERS (2021)
Active and Passive Destabilization of G-Quadruplex DNA by the Telomere POT1-TPP1 Complex
Mengyuan Xu et al.
JOURNAL OF MOLECULAR BIOLOGY (2021)
G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy
Annoor Awadasseid et al.
BIOMEDICINE & PHARMACOTHERAPY (2021)
How to untie G-quadruplex knots and why?
Pauline Lejault et al.
CELL CHEMICAL BIOLOGY (2021)
Synthetic lethality as an engine for cancer drug target discovery
Alan Huang et al.
NATURE REVIEWS DRUG DISCOVERY (2020)
A guide to computational methods for G-quadruplex prediction
Emilia Puig Lombardi et al.
NUCLEIC ACIDS RESEARCH (2020)
G-Quadruplex-Binding Small Molecule Induces Synthetic Lethality in Breast Cancer Cells by Inhibiting c-MYC and BCL2 Expression
Rakesh Paul et al.
CHEMBIOCHEM (2020)
Kinetics, conformation, stability, and targeting of G-quadruplexes from a physiological perspective
Zheng Tan et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies
Josue Carvalho et al.
TRENDS IN MOLECULAR MEDICINE (2020)
Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks
Jia-Min Zhang et al.
CELL AND BIOSCIENCE (2020)
The regulation and functions of DNA and RNA G-quadruplexes
Dhaval Varshney et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Specific stabilization of promoter G-Quadruplex DNA by 2,6-disubstituted amidoanthracene-9,10-dione based dimeric distamycin analogues and their selective cancer cell cytotoxicity
Soma Roy et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Syntheses and Evaluation of New Bisacridine Derivatives for Dual Binding of G-Quadruplex and i-Motif in Regulating Oncogene c-myc Expression
Guotao Kuang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
G-Quadruplexes at Telomeres: Friend or Foe?
Tracy M. Bryan
MOLECULES (2020)
The long noncoding RNA LUCAT1 promotes colorectal cancer cell proliferation by antagonizing Nucleolin to regulate MYC expression
Runliu Wu et al.
CELL DEATH & DISEASE (2020)
A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma
Snehal M. Gaikwad et al.
CANCERS (2020)
Human MYC G-quadruplex: From discovery to a cancer therapeutic target
Wenmeng Wang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)
Structural basis for stabilization of human telomeric G-quadruplex [d-(TTAGGGT)]4 by anticancer drug epirubicin
Ritu Barthwal et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer
Victoria Sanchez-Martin et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back
Prakash Kharel et al.
NUCLEIC ACIDS RESEARCH (2020)
G-quadruplex-R-loop interactions and the mechanism of anticancer G-quadruplex binders
Giulia Miglietta et al.
NUCLEIC ACIDS RESEARCH (2020)
Drug-like biimidazole derivatives dually target c-MYC/BCL-2 G-quadruplexes and inhibit acute myeloid leukemia
Ming-Hao Hu et al.
BIOORGANIC CHEMISTRY (2020)
Development of synthetic lethality in cancer: molecular and cellular classification
Shijie Li et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
The Structure and Function of DNA G-Quadruplexes
Jochen Spiegel et al.
TRENDS IN CHEMISTRY (2020)
Naphthalene Diimides as Multimodal G-Quadruplex-Selective Ligands
Valentina Pirota et al.
MOLECULES (2019)
Distinct biological responses of metastatic castration resistant prostate cancer cells upon exposure to G-quadruplex interacting naphthalenediimide derivatives
Marta Recagni et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
The diverse structural landscape of quadruplexes
Helen L. Lightfoot et al.
FEBS LETTERS (2019)
G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells
F. Berardinelli et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)
Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC
Kai-Bo Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Genetic interactions of G-quadruplexes in humans
Katherine G. Zyner et al.
ELIFE (2019)
AS1411 derivatives as carriers of G-quadruplex ligands for cervical cancer cells
Joana Figueiredo et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)
The Oncogenic Signaling Pathways in BRAF-Mutant Melanoma Cells Are Modulated by Naphthalene Diimide-Like G-Quadruplex Ligands
Marta Recagni et al.
CELLS (2019)
The G-quadruplex-stabilizing ligand RHPS4 enhances sensitivity of U251MG glioblastoma cells to clinical carbon ion beams
Francesco Berardinelli et al.
FEBS JOURNAL (2018)
Platinum Complexes Can Bind to Telomeres by Coordination
Lina Saker et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Down-Regulation of the Androgen Receptor by G-Quadruplex Ligands Sensitizes Castration-Resistant Prostate Cancer Cells to Enzalutamide
Martina Tassinari et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction
Yu-Qing Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
A Cisplatin Derivative Tetra-Pt(bpy) as an Oncotherapeutic Agent for Targeting ALT Cancer
Xiao-hui Zheng et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)
DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
Robert Hansel-Hertsch et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Hong Xu et al.
NATURE COMMUNICATIONS (2017)
A Cisplatin Derivative Tetra-Pt(bpy) as an Oncotherapeutic Agent for Targeting ALT Cancer
Xiao-hui Zheng et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)
G-quadruplexes in human promoters: A challenge for therapeutic applications
Riccardo Rigo et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)
Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization
Roberta Rocca et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)
Synthesis, Binding Properties, and Differences in Cell Uptake of G-Quadruplex Ligands Based on Carbohydrate Naphthalene Diimide Conjugates
Matilde Arevalo-Ruiz et al.
CHEMISTRY-A EUROPEAN JOURNAL (2017)
Nemorubicin and doxorubicin bind the G-quadruplex sequences of the human telomeres and of the c-MYC promoter element Pu22
Leonardo Scaglioni et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2016)
Optimized Virtual Screening Workflow for the Identification of Novel G-Quadruplex Ligands
Teresa Kaserer et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2016)
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds
Jutta Zimmer et al.
MOLECULAR CELL (2016)
Emerging Role of G-quadruplex DNA as Target in Anticancer Therapy
Graziella Cimino-Reale et al.
CURRENT PHARMACEUTICAL DESIGN (2016)
Folding Kinetics of Single Human Telomeric G-Quadruplex Affected by Cisplatin
Hai-Peng Ju et al.
ACS OMEGA (2016)
The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells
F. Berardinelli et al.
DNA REPAIR (2015)
G4-associated human diseases
Nancy Maizels
EMBO REPORTS (2015)
Water-soluble isoindolo[2,1-a] quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action
Barbara Parrino et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer
Stephan A. Ohnmacht et al.
SCIENTIFIC REPORTS (2015)
Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery?
Lucia Parrotta et al.
EXPERT OPINION ON DRUG DISCOVERY (2014)
Detection of G-quadruplex DNA in mammalian cells
Alexander Henderson et al.
NUCLEIC ACIDS RESEARCH (2014)
Elevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer Tissues
Giulia Biffi et al.
PLOS ONE (2014)
On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts
Sara Iachettini et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2013)
G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells
Keith I. E. McLuckie et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
G4LDB: a database for discovering and studying G-quadruplex ligands
Qian Li et al.
NUCLEIC ACIDS RESEARCH (2013)
G-quadruplex structures are stable and detectable in human genomic DNA
Enid Yi Ni Lam et al.
NATURE COMMUNICATIONS (2013)
G4 motifs in human genes
Nancy Maizels
EFFECTS OF GENOME STRUCTURE AND SEQUENCE ON VARIATION AND EVOLUTION (2012)
Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage
Nicola Ivan Orlotti et al.
AUTOPHAGY (2012)
Screening of a Chemical Library by HT-G4-FID for Discovery of Selective G-quadruplex Binders
Eric Largy et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes
Raphael Rodriguez et al.
NATURE CHEMICAL BIOLOGY (2012)
Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics
Mustapha Haddach et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
G-quadruplexes in RNA biology
Stefania Millevoi et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2012)
Development of a high-throughput G4-FID assay for screening and evaluation of small molecules binding quadruplex nucleic acid structures
Eric Largy et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2011)
A structural analysis of G-quadruplex/ligand interactions
Shozeb M. Haider et al.
BIOCHIMIE (2011)
Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
Denis Drygin et al.
CANCER RESEARCH (2011)
The application of DNA and RNA G-quadruplexes to therapeutic medicines
Gavin W. Collie et al.
CHEMICAL SOCIETY REVIEWS (2011)
DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents
Annamaria Biroccio et al.
CLINICAL CANCER RESEARCH (2011)
Affinity of the anthracycline antitumor drugs Doxorubicin and Sabarubicin for human telomeric G-quadruplex structures
Ilse Manet et al.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2011)
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress
Monika Aggarwal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Making sense of G-quadruplex and i-motif functions in oncogene promoters
Tracy A. Brooks et al.
FEBS JOURNAL (2010)
PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy
E. Salvati et al.
ONCOGENE (2010)
Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)](4)
Bruno Pagano et al.
JOURNAL OF NUCLEIC ACIDS (2010)
Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis
Denis Drygin et al.
CANCER RESEARCH (2009)
Platination of telomeric sequences and nuclease hypersensitive elements of human c-myc and PDGF-A promoters and their ability to form G-quadruplexes
Viktor Viglasky
FEBS JOURNAL (2009)
DNA adducts of antitumor cisplatin preclude telomeric sequences from forming G quadruplexes
Pavla Heringova et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2009)
Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule
Mekala Gunaratnam et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
G-quadruplexes: Targets in anticancer drug design
Tian-miao Ou et al.
CHEMMEDCHEM (2008)
G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors
Carlo Leonetti et al.
CLINICAL CANCER RESEARCH (2008)
Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism
P. Phatak et al.
BRITISH JOURNAL OF CANCER (2007)
GG sequence of DNA and the human telomeric sequence react with cis-diammine-diaquaplatinum at comparable rates
Isabelle Ourliac-Garnier et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2007)
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells
Dennis Gomez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence
C Douarre et al.
NUCLEIC ACIDS RESEARCH (2005)
Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration
D Gomez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Specific interactions of distamycin with G-quadruplex DNA
MJ Cocco et al.
NUCLEIC ACIDS RESEARCH (2003)
Structure of the first parallel DNA quadruplex-drug complex
GR Clark et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)