4.7 Review

The Impact of the Circadian Clock on Skin Physiology and Cancer Development

Related references

Note: Only part of the references are listed.
Review Medicine, Research & Experimental

Molecular Pathogenesis of Merkel Cell Carcinoma

James A. DeCaprio

Summary: Merkel cell carcinoma (MCC) has two distinct etiologies, with one caused by viral DNA integration and the other by UV damage. Despite different causes, both forms of MCC have similar presentation, prognosis, and response to therapy. Oncogenic transcriptional programs, cell proliferation rates, and neuroendocrine differentiation programs play important roles in both types of MCC.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

Article Dermatology

Expression of antimicrobial peptide genes oscillates along day/night rhythm protecting mice skin from bacteria

Bernadetta Bilska et al.

Summary: The gene expression of Rarres2, Camp, and Defb1 in mouse skin was highest during high activity periods, but this rhythm was masked under constant darkness, while the gene expression of Defb3 and Defb14 showed the highest levels during sleep and were maintained under constant darkness. This indicates a correlation between specific antimicrobial peptides and different physiological states, with some being influenced by light-dark cycles and others being regulated by a circadian clock.

EXPERIMENTAL DERMATOLOGY (2021)

Article Dermatology

Cryptochrome 1 is modulated by blue light in human keratinocytes and exerts positive impact on human hair growth

Serena Buscone et al.

Summary: The study demonstrates that 453 nm blue light induces the accumulation of CRY1 in human keratinocytes and hair follicles. CRY1 plays a role in sustaining human hair growth by affecting the expression of genes related to apoptosis and proliferation.

EXPERIMENTAL DERMATOLOGY (2021)

Review Dermatology

Xeroderma Pigmentosum: A Model for Human Premature Aging

Elizabeth R. H. Rizza et al.

Summary: XP is a unique model of human premature aging, which is revealing new insights into aging mechanisms. The primary cutaneous features of XP include poikiloderma, atypical lentigines, and skin cancers, which also occur in the general population but at a much older age. XP patients also exhibit internal manifestations of premature aging, such as peripheral neuropathy, progressive sensorineural hearing loss, and neurodegeneration.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Review Biotechnology & Applied Microbiology

Circadian rhythm as a therapeutic target

Wei Ruan et al.

Summary: The circadian clock plays a crucial role in integrating external environmental changes and internal physiology, providing temporal precision and robust adaptation to the environment. Disruption of circadian rhythms can lead to adverse health consequences, but there is still an underappreciation of how to take advantage of biological timing for health benefits. Promising progress in research and clinical applications should drive efforts towards a new era of circadian medicine.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Dermatology

Vitamin D Receptor Promotes Global Nucleotide Excision Repair by Facilitating XPC Dissociation from Damaged DNA

Christian T. Wong et al.

Summary: Vitamin D receptor (VDR) plays a crucial role in the repair of UV-induced DNA damage by facilitating the dissociation of XPC from damaged DNA, allowing for the recruitment and assembly of other repair proteins to proceed normally.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Article Anatomy & Morphology

Neuronal PAS Domain 2 (Npas2)-Deficient Fibroblasts Accelerate Skin Wound Healing and Dermal Collagen Reconstruction

Hodaka Sasaki et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2020)

Article Biochemistry & Molecular Biology

BMAL1 Modulates Epidermal Healing in a Process Involving the Antioxidative Defense Mechanism

Ericka J. D. Silveira et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Circadian control of interferon-sensitive gene expression in murine skin

Elyse Noelani Greenberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Medicine, Legal

Arsenic exposure: A public health problem leading to several cancers

I. Palma-Lara et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2020)

Article Multidisciplinary Sciences

Circadian rhythms in the absence of the clock gene Bmal1

Sandipan Ray et al.

SCIENCE (2020)

Review Biochemistry & Molecular Biology

Vitamin D Signaling in Inflammation and Cancer: Molecular Mechanisms and Therapeutic Implications

Ahmed El-Sharkawy et al.

MOLECULES (2020)

Review Dermatology

DNA repair enzymes in sunscreens and their impact on photoageing-A systematic review

Hanna Luze et al.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2020)

Article Pharmacology & Pharmacy

The circadian clock protects against acute radiation-induced dermatitis

Panshak P. Dakup et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)

Review Medicine, Research & Experimental

Association between circadian disruption and diseases: A narrative review

Yuchao Hou et al.

LIFE SCIENCES (2020)

Article Dermatology

Skin typing: Fitzpatrick grading and others

Vishal Gupta et al.

CLINICS IN DERMATOLOGY (2019)

Editorial Material Multidisciplinary Sciences

Dosing time matters

Marc D. Ruben et al.

SCIENCE (2019)

Article Dermatology

Ultraviolet B radiation modifies circadian time in epidermal skin and in subcutaneous adipose tissue

Veera Nikkola et al.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2019)

Article Clinical Neurology

The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer

Monica N. Morgan et al.

CLOCKS & SLEEP (2019)

Article Dermatology

Circadian rhythm in atopic dermatitisPathophysiology and implications for chronotherapy

Alexandra R. Vaughn et al.

PEDIATRIC DERMATOLOGY (2018)

Review Pharmacology & Pharmacy

Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems

Zheng Chen et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58 (2018)

Article Biochemistry & Molecular Biology

Non-Metastatic Cutaneous Melanoma Induces Chronodisruption in Central and Peripheral Circadian Clocks

Leonardo Vinicius Monteiro de Assis et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Letter Dermatology

Differential Day-Night Outcome to HSV-2 Cutaneous Infection

Takamitsu Matsuzawa et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Letter Dermatology

Circadian Time Effects on NB-UVB-Induced Erythema in Human Skin In Vivo

Veera Nikkola et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Article Dermatology

Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age

Alexa B. Kimball et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

Article Multidisciplinary Sciences

External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway

Sabrina Mai-Yi Fan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Medicine, Legal

A review on arsenic carcinogenesis: Epidemiology, metabolism, genotoxicity and epigenetic changes

Qing Zhou et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2018)

Review Environmental Sciences

Solar Radiation Exposure and Outdoor Work: An Underestimated Occupational Risk

Alberto Modenese et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Article Multidisciplinary Sciences

Population-level rhythms in human skin with implications for circadian medicine

Gang Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Dermatology

Human long-term deregulated circadian rhythm alters regenerative properties of skin and hair precursor cells

Nathalie Deshayes et al.

EUROPEAN JOURNAL OF DERMATOLOGY (2018)

Review Endocrinology & Metabolism

How UV Light Touches the Brain and Endocrine System Through Skin, and Why

Andrzej T. Slominski et al.

ENDOCRINOLOGY (2018)

Review Biochemistry & Molecular Biology

Non Melanoma Skin Cancer Pathogenesis Overview

Dario Didona et al.

BIOMEDICINES (2018)

Review Genetics & Heredity

Transcriptional architecture of the mammalian circadian clock

Joseph S. Takahashi

NATURE REVIEWS GENETICS (2017)

Article Cell Biology

Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing

Nathaniel P. Hoyle et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Letter Genetics & Heredity

The circadian clock system's influence in health and disease

Joseph T. Bass

GENOME MEDICINE (2017)

Article Cell & Tissue Engineering

PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells

Chiara Zagni et al.

STEM CELL REPORTS (2017)

Review Clinical Neurology

Clock-enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging

Gabrielle F. Gloston et al.

FRONTIERS IN NEUROLOGY (2017)

Article Chemistry, Multidisciplinary

Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)

Aziz Sancar

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Review Dermatology

Ultraviolet exposure from indoor tanning devices: a systematic review

L. T. N. Nilsen et al.

BRITISH JOURNAL OF DERMATOLOGY (2016)

Review Dermatology

Knowledge of outdoor workers on the effects of natural UV radiation and methods of protection against exposure

K. Hault et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2016)

Article Biochemistry & Molecular Biology

Peripheral Skin Temperature and Circadian Biological Clock in Shift Nurses after a Day off

Massimo Bracci et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Biochemistry & Molecular Biology

A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells

Sung Kook Chun et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Dermatology

Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice

Noriko Ando et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

Article Dermatology

The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin

Shobhan Gaddameedhi et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

Article Dermatology

The Peripheral Clock Regulates Human Pigmentation

Jonathan A. Hardman et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

Article Medicine, General & Internal

Skin Cancer Epidemiology, Detection, and Management

Sumul Ashok Gandhi et al.

MEDICAL CLINICS OF NORTH AMERICA (2015)

Article Primary Health Care

Skin Cancer

Miguel A. Linares et al.

PRIMARY CARE (2015)

Article Multidisciplinary Sciences

Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure

Sanjay Premi et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Circadian Modulation of 8-Oxoguanine DNA Damage Repair

Nicola Manzella et al.

SCIENTIFIC REPORTS (2015)

Review Biochemistry & Molecular Biology

UV Signature Mutations

Douglas E. Brash

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2015)

Article Dermatology

24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is Regulated by Molecular Clocks

Naoya Matsunaga et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Article Multidisciplinary Sciences

A circadian gene expression atlas in mammals: Implications for biology and medicine

Ray Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Genetics & Heredity

Ras-Mediated Deregulation of the Circadian Clock in Cancer

Angela Relogio et al.

PLOS GENETICS (2014)

Article Dermatology

The clock gene brain and muscle Arnt-like protein-1 (BMAL1) is involved in hair growth

Yuichi Watabe et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2013)

Article Dermatology

Biological clock dysfunction exacerbates contact hypersensitivity in mice

E. Takita et al.

BRITISH JOURNAL OF DERMATOLOGY (2013)

Article Cell & Tissue Engineering

Human Epidermal Stem Cell Function Is Regulated by Circadian Oscillations

Peggy Janich et al.

CELL STEM CELL (2013)

Article Multidisciplinary Sciences

NONO couples the circadian clock to the cell cycle

Elzbieta Kowalska et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling

Maksim V. Plikus et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Public, Environmental & Occupational Health

Melanoma Treatment Costs A Systematic Review of the Literature, 1990-2011

Gery P. Guy et al.

AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2012)

Review Neurosciences

Central and Peripheral Circadian Clocks in Mammals

Jennifer A. Mohawk et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 35 (2012)

Article Biochemistry & Molecular Biology

Rhythmic expression of circadian clock genes in human leukocytes and beard hair follicle cells

Makiko Watanabe et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Biochemistry & Molecular Biology

Human skin keratinocytes, melanocytes, and fibroblasts contain distinct circadian clock machineries

Cristina Sandu et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Review Dermatology

Shining a Light on Xeroderma Pigmentosum

John J. DiGiovanna et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

Review Medicine, General & Internal

Melanoma in Immunosuppressed Patients

Agnieszka W. Kubica et al.

MAYO CLINIC PROCEEDINGS (2012)

Article Multidisciplinary Sciences

Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes

Florian Spoerl et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

Mikhail Geyfman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Genetics & Heredity

Genetic insights on sleep schedules: this time, it's PERsonal

S. Y. Christin Chong et al.

TRENDS IN GENETICS (2012)

Article Biochemistry & Molecular Biology

Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB

Douglas Kojetin et al.

ACS CHEMICAL BIOLOGY (2011)

Article Dermatology

A Circadian Clock in HaCaT Keratinocytes

Florian Spoerl et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

Article Multidisciplinary Sciences

The circadian molecular clock creates epidermal stem cell heterogeneity

Peggy Janich et al.

NATURE (2011)

Review Biochemistry & Molecular Biology

The Consequences of UV-Induced Immunosuppression for Human Health

Mary Norval et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2011)

Article Multidisciplinary Sciences

Control of skin cancer by the circadian rhythm

Shobhan Gaddameedhi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Nursing

Evidence-Based Skin Care Management in Radiation Therapy: Clinical Update

Maurene McQuestion

Seminars in Oncology Nursing (2011)

Article Biochemistry & Molecular Biology

Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORα and RORγ

Yongjun Wang et al.

ACS CHEMICAL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Circadian clock control of the cellular response to DNA damage

Aziz Sancar et al.

FEBS LETTERS (2010)

Article Oncology

The Economic Impact of Non-Melanoma Skin Cancer: A Review

Tejaswi Mudigonda et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2010)

Article Multidisciplinary Sciences

Noninvasive method for assessing the human circadian clock using hair follicle cells

Makoto Akashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

Tae-Hong Kang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Genetics & Heredity

Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling

Kevin K. Lin et al.

PLOS GENETICS (2009)

Review Biochemistry & Molecular Biology

Defective DNA repair and Neurodegenerative disease

Ulrich Rass et al.

Article Genetics & Heredity

Oxidative damage to purines in DNA: Role of mammalian Ogg1

Arne Klungland et al.

DNA REPAIR (2007)

Article Multidisciplinary Sciences

Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation

Stephane Mouret et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

The period length of fibroblast circadian gene expression varies widely among human individuals

SA Brown et al.

PLOS BIOLOGY (2005)

Review Medicine, General & Internal

Medical progress - Skin cancers after organ transplantation

S Euvrard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Article Dermatology

Expression of the circadian clock genes clock and period 1 in human skin

SB Zanello et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2000)